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Protein IGFBP4 PDB 1wqj.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesIGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4, insulin like growth factor binding protein 4
External IDsOMIM: 146733 MGI: 96439 HomoloGene: 1192 GeneCards: IGFBP4
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 40.44 – 40.46 MbChr 11: 98.93 – 98.95 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.[5][6][7]


This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.[8] IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.

Clinical significance

The protein itself does not prevent the formation of cancer.[9] However it may reduce the growth of cancer and act as an apoptotic factor.


IGFBP4 has been shown to interact with Insulin-like growth factor 1 and 2.[10][11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141753 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017493 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ LaTour D, Mohan S, Linkhart TA, Baylink DJ, Strong DD (May 1991). "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation". Mol Endocrinol. 4 (12): 1806–14. doi:10.1210/mend-4-12-1806. PMID 1707125.
  6. ^ Shimasaki S, Uchiyama F, Shimonaka M, Ling N (Mar 1991). "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human". Mol Endocrinol. 4 (10): 1451–8. doi:10.1210/mend-4-10-1451. PMID 1704481.
  7. ^ Zazzi H, Nikoshkov A, Hall K, Luthman H (1998). "Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4)". Genomics. 49 (3): 401–10. doi:10.1006/geno.1998.5283. PMID 9615225.
  8. ^ "Entrez Gene: IGFBP4 insulin-like growth factor binding protein 4".
  9. ^ Durai R, Yang SY, Seifalian AM, Goldspink G, Winslet MC (2007). "Role of insulin-like growth factor binding protein-4 in prevention of colon cancer". World J Surg Oncol. 5: 128. doi:10.1186/1477-7819-5-128. PMC 2203999. PMID 17988381.
  10. ^ Bach LA, Hsieh S, Sakano K, Fujiwara H, Perdue JF, Rechler MM (May 1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. doi:10.1016/S0021-9258(18)98342-0. PMID 7683646.
  11. ^ Qin X, Strong DD, Baylink DJ, Mohan S (Sep 1998). "Structure-function analysis of the human insulin-like growth factor binding protein-4". J. Biol. Chem. 273 (36): 23509–16. doi:10.1074/jbc.273.36.23509. PMID 9722589.

Further reading