|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||270.240 g·mol−1|
|3D model (JSmol)|
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from tropoflavin (7,8-DHF). Relative to tropoflavin, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist. 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than tropoflavin in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity. 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to tropoflavin.
- Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry. 53 (23): 8274–86. doi:10.1021/jm101206p. PMC 3150605. PMID 21073191.
- Yu Q, Chang Q, Liu X, Gong S, Ye K, Lin X (June 2012). "7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo". Biochemical and Biophysical Research Communications. 422 (3): 387–92. doi:10.1016/j.bbrc.2012.04.154. PMC 3388121. PMID 22575512.
- Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, et al. (August 2013). "Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists". The Journal of Neuroscience. 33 (32): 13042–52. doi:10.1523/JNEUROSCI.0854-13.2013. PMC 3735884. PMID 23926258.