|Pronunciation||dak" oh mi' ti nib|
|Drug class||EGFR inhibitor|
|Main uses||Non-small-cell lung carcinoma (NSCLC)|
|Typical dose||45 mg OD|
|Elimination half-life||70 hrs|
|Excretion||79% faeces, 3% urine|
|Chemical and physical data|
|Molar mass||469.95 g·mol−1|
|3D model (JSmol)|
Dacomitinib, sold under the brand name Vizimpro, is a medication used to treat non-small-cell lung carcinoma (NSCLC). Specifically it is used for cases with certain epidermal growth factor receptor (EGFR) mutations. It is taken by mouth.
Common side effects include diarrhea, rash, mouth inflammation, conjunctivitis, itching, liver problems, and nausea. Other side effects may include interstitial lung disease. Use in pregnancy may harm the baby. It is a tyrosine kinase inhibitor of EGFR.
Dacomitinib was approved for medical use in the United States in 2018 and Europe in 2019. In the United States it costs about 14,300 USD per month as of 2021. This amount in the United Kingdom costs the NHS about £2,700.
The typical dose is 45 mg per day.
Dacomitinib has advanced to several Phase III clinical trials.[when?] The January 2014 results of the first trials were disappointing, with a failure to meet the study goals. Additional Phase III trials are ongoing[when?].
- "Dacomitinib". NCI Drug Dictionary. National Cancer Institute, U.S. Department of Health and Human Services.
- "Dacomitinib Monograph for Professionals". Drugs.com. Retrieved 17 December 2021.
- "Vizimpro EPAR". European Medicines Agency (EMA). 5 June 2019. Retrieved 13 December 2019.
- "Vizimpro Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 17 December 2021.
- BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1021. ISBN 978-0857114105.
- Chustecka Z (27 January 2014). "Dacomitinib Fails in Pretreated Non-small Cell Lung Cancer". Medscape.
- Taylor P (28 January 2014). "Blow to Pfizer as dacomitinib fails in lung cancer trials". pmlive.com.
- "Pfizer Announces Top-Line Results From Two Phase 3 Trials Of Dacomitinib In Patients With Refractory Advanced Non-Small Cell Lung Cancer". Pfizer Press Release. 27 January 2014.