IGFBP1

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IGFBP1
Protein IGFBP1 PDB 1zt3.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
External IDsOMIM: 146730 MGI: 96436 HomoloGene: 498 GeneCards: IGFBP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001013029
NM_000596

NM_008341

RefSeq (protein)

NP_000587

NP_032367

Location (UCSC)Chr 7: 45.89 – 45.89 MbChr 11: 7.2 – 7.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.[5][6]

Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146678 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020429 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL (Jan 1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J. 7 (8): 2417–23. doi:10.1002/j.1460-2075.1988.tb03087.x. PMC 457109. PMID 2461294.
  6. ^ a b "Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1".

Further reading