Cytomegalovirus colitis

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Cytomegalovirus colitis
Other names: CMV colitis
Micrograph of CMV colitis. H&E stain.
SpecialtyInfectious disease

Cytomegalovirus colitis, also known as CMV colitis, is an inflammation of the colon.

Signs and symptoms

The clinical presentation of CMV colitis is consistent with the following:[1]


The infection is spread by saliva, urine, respiratory droplets, sexual contact, and blood transfusions. Most people are exposed to the virus in their lifetime, but it usually produces mild or no symptoms in healthy people.[citation needed]

However, serious CMV infections can occur in people with weakened immune systems. This includes patients receiving chemotherapy for cancer and patients on immune-suppressing medicines following an organ transplant.[citation needed]

In rare instances, more severe CMV infection involving the GI tract has been reported in people with a healthy immune system.[citation needed]

Risk factors

The systemic use of corticosteroids in the context of inflammatory bowel disease.[2]


Cytomegalovirus colitis - a)Cytomegalovirus in endothelial cell b) immunohistochemistry of cytomegalovirus-infected cells

CMV colitis may be clinically manifested with diarrhea (usually non-bloody), abdominal pain, weight loss and anorexia. The diagnosis of CMV colitis is based on serology, CMV antigen testing and colonoscopy with biopsy. Clinical suspicion should be aroused in the setting of immunocompromised patient but it is much rarer in immunocompetent patient. Although it is known that CMV colitis is almost always caused by reactivation of latent CMV infection in immunocompromised patients, new infection of CMV or reinfection of different strain of CMV can cause colitis in immunocompetent hosts. Because asymptomatic CMV viremia and viruria is common and about 1/3 of symptomatic CMV infection is caused by reinfection of different strain of CMV, the diagnosis of CMV colitis needs more direct causality. It is practically achieved by colonoscopy or sigmoidoscopy tissue sampling and pathological evidence of CMV infection under microscope, more specifically macroscopic picture will show many ulcers that appear on the mucous membrane and microscopically the biopsy will show intranuclear and cytoplasmic inclusion bodies. Positive CMV IgG doesn't necessarily mean that it is reactivation of latent infection because of the possibility of reinfection of different strain.[citation needed]


The usual treatment is antivirals, specifically ganciclovir or valganciclovir.[2] Severe CMV colitis may lead a colectomy.[3]

See also


  1. Azer, Samy A.; Limaiem, Faten (2022). "Cytomegalovirus Colitis". StatPearls. StatPearls Publishing. Archived from the original on 17 March 2022. Retrieved 1 May 2022.
  2. 2.0 2.1 Kandiel A, Lashner B (December 2006). "Cytomegalovirus colitis complicating inflammatory bowel disease". Am. J. Gastroenterol. 101 (12): 2857–65. PMID 17026558.
  3. Lawlor G, Moss AC (September 2010). "Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander?". Inflamm. Bowel Dis. 16 (9): 1620–7. doi:10.1002/ibd.21275. PMID 20232408. S2CID 9785434.