|Other names: Epityphlitis|
|An acutely inflamed and enlarged appendix, sliced lengthwise.|
|Symptoms||Right lower abdominal pain, vomiting, decreased appetite|
|Complications||Abdominal inflammation, sepsis|
|Diagnostic method||Based on symptoms, medical imaging, blood tests|
|Differential diagnosis||Mesenteric adenitis, cholecystitis, psoas abscess, abdominal aortic aneurysm|
|Treatment||Surgical removal of the appendix, antibiotics|
|Frequency||11.6 million (2015)|
Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain, nausea, vomiting, and decreased appetite. However, approximately 40% of people do not have these typical symptoms. Severe complications of a ruptured appendix include widespread, painful inflammation of the inner lining of the abdominal wall and sepsis.
Appendicitis is caused by a blockage of the hollow portion of the appendix. This is most commonly due to a calcified "stone" made of feces. Inflamed lymphoid tissue from a viral infection, parasites, gallstone, or tumors may also cause the blockage. This blockage leads to increased pressures in the appendix, decreased blood flow to the tissues of the appendix, and bacterial growth inside the appendix causing inflammation. The combination of inflammation, reduced blood flow to the appendix and distention of the appendix causes tissue injury and tissue death. If this process is left untreated, the appendix may burst, releasing bacteria into the abdominal cavity, leading to increased complications.
The diagnosis of appendicitis is largely based on the person's signs and symptoms. In cases where the diagnosis is unclear, close observation, medical imaging, and laboratory tests can be helpful. The two most common imaging tests used are an ultrasound and computed tomography (CT scan). CT scan has been shown to be more accurate than ultrasound in detecting acute appendicitis. However, ultrasound may be preferred as the first imaging test in children and pregnant women because of the risks associated with radiation exposure from CT scans.
The standard treatment for acute appendicitis is surgical removal of the appendix. This may be done by an open incision in the abdomen (laparotomy) or through a few smaller incisions with the help of cameras (laparoscopy). Surgery decreases the risk of side effects or death associated with rupture of the appendix. Antibiotics may be equally effective in certain cases of non-ruptured appendicitis. It is one of the most common and significant causes of severe abdominal pain that comes on quickly. In 2015 about 11.6 million cases of appendicitis occurred which resulted in about 50,100 deaths. In the United States, appendicitis is the most common cause of sudden abdominal pain requiring surgery. Each year in the United States, more than 300,000 people with appendicitis have their appendix surgically removed. Reginald Fitz is credited with being the first person to describe the condition in 1886.
Signs and symptoms
The presentation of acute appendicitis includes abdominal pain, nausea, vomiting, and fever. As the appendix becomes more swollen and inflamed, it begins to irritate the adjoining abdominal wall. This leads to the localization of the pain to the right lower quadrant. This classic migration of pain may not be seen in children under three years. This pain can be elicited through signs and can be severe. Symptoms include localized findings in the right iliac fossa. The abdominal wall becomes very sensitive to gentle pressure (palpation). There is severe pain in the sudden release of deep tension in the lower abdomen (rebound tenderness). If the appendix is retrocecal (localized behind the cecum), even deep pressure in the right lower quadrant may fail to elicit tenderness (silent appendix). This is because the cecum, distended with gas, protects the inflamed appendix from pressure. Similarly, if the appendix lies entirely within the pelvis, there is typically a complete absence of abdominal rigidity. In such cases, a digital rectal examination elicits tenderness in the rectovesical pouch. Coughing causes point tenderness in this area (McBurney's point), historically called Dunphy's sign.
Acute appendicitis seems to be the result of a primary obstruction of the appendix. Once this obstruction occurs, the appendix becomes filled with mucus and swells. This continued production of mucus leads to increased pressures within the lumen and the walls of the appendix. The increased pressure results in thrombosis and occlusion of the small vessels, and stasis of lymphatic flow. At this point, spontaneous recovery rarely occurs. As the occlusion of blood vessels progresses, the appendix becomes ischemic and then necrotic. As bacteria begin to leak out through the dying walls, pus forms within and around the appendix (suppuration). The end result is appendiceal rupture (a 'burst appendix') causing peritonitis, which may lead to sepsis and eventually death. These events are responsible for the slowly evolving abdominal pain and other commonly associated symptoms.
The causative agents include bezoars, foreign bodies, trauma, intestinal worms, lymphadenitis and, most commonly, calcified fecal deposits that are known as appendicoliths or fecaliths. The occurrence of obstructing fecaliths has attracted attention since their presence in people with appendicitis is higher in developed than in developing countries. In addition an appendiceal fecalith is commonly associated with complicated appendicitis. Fecal stasis and arrest may play a role, as demonstrated by people with acute appendicitis having fewer bowel movements per week compared with healthy controls.
The occurrence of a fecalith in the appendix was thought to be attributed to a right-sided fecal retention reservoir in the colon and a prolonged transit time. However, a prolonged transit time was not observed in subsequent studies. Diverticular disease and adenomatous polyps was historically unknown and colon cancer was exceedingly rare in communities where appendicitis itself was rare or absent, such as various African communities. Studies have implicated a transition to a Western diet lower in fibre in rising frequencies of appendicitis as well as the other aforementioned colonic diseases in these communities. And acute appendicitis has been shown to occur antecedent to cancer in the colon and rectum. Several studies offer evidence that a low fiber intake is involved in the pathogenesis of appendicitis. This low intake of dietary fiber is in accordance with the occurrence of a right-sided fecal reservoir and the fact that dietary fiber reduces transit time.
Diagnosis is based on a medical history (symptoms) and physical examination, which can be supported by an elevation of neutrophilic white blood cells and imaging studies if needed. Histories fall into two categories, typical and atypical.
Typical appendicitis includes several hours of generalized abdominal pain that begins in the region of the umbilicus with associated anorexia, nausea, or vomiting. The pain then "localizes" into the right lower quadrant where the tenderness increases in intensity. It is possible the pain could localize to the left lower quadrant in people with situs inversus totalis. The combination of pain, anorexia, leukocytosis, and fever is classic.
Atypical histories lack this typical progression and may include pain in the right lower quadrant as an initial symptom. Irritation of the peritoneum (inside lining of the abdominal wall) can lead to increased pain on movement, or jolting, for example going over speed bumps. Atypical histories often require imaging with ultrasound or CT scanning.
- Aure-Rozanova's sign: Increased pain on palpation with finger in right Petit triangle (can be a positive Shchetkin-Bloomberg's).
- Bartomier-Michelson's sign: Increased pain on palpation at the right iliac region as the person being examined lies on their left side compared to when they lie on their back.
- Dunphy's sign: Increased pain in the right lower quadrant with coughing.
- Hamburger sign: The patient refuses to eat (anorexia is 80% sensitive for appendicitis)
- Kocher's (Kosher's) sign: From the person's medical history, the start of pain in the umbilical region with a subsequent shift to the right iliac region.
- Massouh sign: Developed in and popular in southwest England, the examiner performs a firm swish with his or her index and middle finger across the abdomen from the xiphoid process to the left and the right iliac fossa. A positive Massouh sign is a grimace of the person being examined upon a right sided (and not left) sweep.
- Obturator sign: The person being evaluated lies on her or his back with the hip and knee both flexed at ninety degrees. The examiner holds the person's ankle with one hand and knee with the other hand. The examiner rotates the hip by moving the person's ankle away from his or her body while allowing the knee to move only inward. A positive test is pain with internal rotation of the hip.
- Psoas sign, also known as "Obraztsova's sign", is right lower-quadrant pain that is produced with either the passive extension of the right hip or by the active flexion of the person's right hip while supine. The pain that is elicited is due to inflammation of the peritoneum overlying the iliopsoas muscles and inflammation of the psoas muscles themselves. Straightening out the leg causes pain because it stretches these muscles, while flexing the hip activates the iliopsoas and causes pain.
- Rovsing's sign: Pain in the lower right abdominal quadrant with continuous deep palpation starting from the left iliac fossa upwards (counterclockwise along the colon). The thought is there will be increased pressure around the appendix by pushing bowel contents and air toward the ileocaecal valve provoking right-sided abdominal pain.
- Sitkovskiy (Rosenstein)'s sign: Increased pain in the right iliac region as the person is being examined lies on their left side.
Blood and urine test
While there is no laboratory test specific for appendicitis, a complete blood count (CBC) is done to check for signs of infection. Although 70–90 percent of people with appendicitis may have an elevated white blood cell (WBC) count, there are many other abdominal and pelvic conditions that can cause the WBC count to be elevated. Due to its low sensitivity and specificity, on its own, WBC is not seen as a good indicator of appendicitis.
A urinalysis generally does not show infection, but it is important for determining pregnancy status, especially the possibility of an ectopic pregnancy in women of childbearing age. The urinalysis is also important for ruling out a urinary tract infection as the cause of abdominal pain. The presence of more than 20 WBC per high-power field in the urine is more suggestive of a urinary tract disorder.
In children the clinical examination is important to determine which children with abdominal pain should receive immediate surgical consultation and which should receive diagnostic imaging. Because of the health risks of exposing children to radiation, ultrasound is the preferred first choice with CT scan being a legitimate follow-up if the ultrasound is inconclusive. CT scan is more accurate than ultrasound for the diagnosis of appendicitis in adults and adolescents. CT scan has a sensitivity of 94%, specificity of 95%. Ultrasonography had an overall sensitivity of 86%, a specificity of 81%.
Abdominal ultrasonography, preferably with doppler sonography, is useful to detect appendicitis, especially in children. Ultrasound can show the free fluid collection in the right iliac fossa, along with a visible appendix with increased blood flow when using color Doppler, and noncompressibility of the appendix, as it is essentially walled-off abscess. Other secondary sonographic signs of acute appendicitis include the presence of echogenic mesenteric fat surrounding the appendix and the acoustic shadowing of an appendicolith. In some cases (approximately 5%), ultrasonography of the iliac fossa does not reveal any abnormalities despite the presence of appendicitis. This false-negative finding is especially true of early appendicitis before the appendix has become significantly distended. Also, false-negative findings are more common in adults where larger amounts of fat and bowel gas make visualizing the appendix technically difficult. Despite these limitations, sonographic imaging with experienced hands can often distinguish between appendicitis and other diseases with similar symptoms. Some of these conditions include inflammation of lymph nodes near the appendix or pain originating from other pelvic organs such as the ovaries or Fallopian tubes. Ultrasounds may be either done by the radiology department or by the emergency physician.
A normal appendix without and with compression. Absence of compressibility indicates appendicitis.
Where it is readily available, computed tomography (CT) has become frequently used, especially in people whose diagnosis is not obvious on history and physical examination. Concerns about radiation tend to limit use of CT in pregnant women and children, especially with the increasingly widespread usage of MRI.
The accurate diagnosis of appendicitis is multi-tiered, with the size of the appendix having the strongest positive predictive value, while indirect features can either increase or decrease sensitivity and specificity. A size of over 6 mm is both 95% sensitive and specific for appendicitis.
However, because the appendix can be filled with fecal material, causing intraluminal distention, this criterion has shown limited utility in more recent meta-analyses. This is as opposed to ultrasound, in which the wall of the appendix can be more easily distinguished from intraluminal feces. In such scenarios, ancillary features such as increased wall enhancement as compared to adjacent bowel and inflammation of the surrounding fat, or fat stranding, can be supportive of the diagnosis. However, their absence does not preclude it. In severe cases with perforation, an adjacent phlegmon or abscess can be seen. Dense fluid layering in the pelvis can also result, related to either pus or enteric spillage. When patients are thin or younger, the relative absence of fat can make the appendix and surrounding fat stranding difficult to see.
Magnetic resonance imaging
Magnetic resonance imaging (MRI) use has become increasingly common for diagnosis of appendicitis in children and pregnant patients due to the radiation dosage that, while of nearly negligible risk in healthy adults, can be harmful to children or the developing baby. In pregnancy, it is more useful during the second and third trimester, particularly as the enlargening uterus displaces the appendix, making it difficult to find by ultrasound. The periappendiceal stranding that is reflected on CT by fat stranding on MRI appears as an increased fluid signal on T2 weighted sequences. First trimester pregnancies are usually not candidates for MRI, as the fetus is still undergoing organogenesis, and there are no long-term studies to date regarding its potential risks or side effects.
In general, plain abdominal radiography (PAR) is not useful in making the diagnosis of appendicitis and should not be routinely obtained from a person being evaluated for appendicitis. Plain abdominal films may be useful for the detection of ureteral calculi, small bowel obstruction, or perforated ulcer, but these conditions are rarely confused with appendicitis. An opaque fecalith can be identified in the right lower quadrant in fewer than 5% of people being evaluated for appendicitis. A barium enema has proven to be a poor diagnostic tool for appendicitis. While failure of the appendix to fill during a barium enema has been associated with appendicitis, up to 20% of normal appendices do not fill.
Several scoring systems have been developed to try to identify people who are likely to have appendicitis. The performance of scores such as the Alvarado score and the Pediatric Appendicitis Score, however, are variable.
The Alvarado score is the most known scoring system. A score below 5 suggests against a diagnosis of appendicitis, whereas a score of 7 or more is predictive of acute appendicitis. In a person with an equivocal score of 5 or 6, a CT scan or ultrasound exam may be used to reduce the rate of negative appendectomy.
|Migratory right iliac fossa pain||1 point|
|Nausea and vomiting||1 point|
|Right iliac fossa tenderness||2 points|
|Rebound abdominal tenderness||1 point|
|High white blood cell count (leukocytosis)||2 points|
|Shift to left (segmented neutrophils)||1 point|
|Total score||10 points|
Even for clinically certain appendicitis, routine histopathology examination of appendectomy specimens is of value for identifying unsuspected pathologies requiring further postoperative management. Notably, appendix cancer is found incidentally in about 1% of appendectomy specimens.
|Pattern||Gross pathology||Light microscopy||Clinical significance|
|Acute intraluminal inflammation||None visible||
|Acuta mucosal inflammation||None visible||
||May be secondary to enteritis.|
|Suppurative acute appendicitis||May be inapparent.
||Can be presumed to be primary cause of symptoms|
||Will perforate if untreated|
|Periappendicitis||May be inapparent.
||Probably secondary to other disease|
|Eosinophilic appendicitis||None visible||
||Possibly parasitic, or eosinophilic enteritis.|
Children: Gastroenteritis, mesenteric adenitis, Meckel's diverticulitis, intussusception, Henoch–Schönlein purpura, lobar pneumonia, urinary tract infection (abdominal pain in the absence of other symptoms can occur in children with UTI), new-onset Crohn's disease or ulcerative colitis, pancreatitis, and abdominal trauma from child abuse; distal intestinal obstruction syndrome in children with cystic fibrosis; typhlitis in children with leukemia.
Women: A pregnancy test is important for all women of childbearing age since an ectopic pregnancy can have signs and symptoms similar to those of appendicitis. Other obstetrical/gynecological causes of similar abdominal pain in women include pelvic inflammatory disease, ovarian torsion, menarche, dysmenorrhea, endometriosis, and Mittelschmerz (the passing of an egg in the ovaries approximately two weeks before menstruation).
Men: testicular torsion
Acute appendicitis is typically managed by surgery. While antibiotics are safe and effective for treating uncomplicated appendicitis, 26% of people had a recurrence within a year and required an eventual appendectomy. Antibiotics are less effective if an appendicolith is present. Surgery is the standard management approach for acute appendicitis. The cost effectiveness of surgery versus antibiotics is unclear.
Using antibiotics to prevent potential postoperative complications in emergency appendectomy procedures is recommended, and the antibiotics are effective when given to a person before, during, or after surgery.
Pain medications (such as morphine) do not appear to affect the accuracy of the clinical diagnosis of appendicitis and therefore should be given early in the patient's care. Historically there were concerns among some general surgeons that analgesics would affect the clinical exam in children, and some recommended that they not be given until the surgeon was able to examine the person.
The surgical procedure for the removal of the appendix is called an appendectomy. Appendectomy can be performed through open or laparoscopic surgery. Laparoscopic appendectomy has several advantages over open appendectomy as an intervention for acute appendicitis.
For over a century, laparotomy (open appendectomy) was the standard treatment for acute appendicitis. This procedure consists of the removal of the infected appendix through a single large incision in the lower right area of the abdomen. The incision in a laparotomy is usually 2 to 3 inches (51 to 76 mm) long.
During an open appendectomy, the person with suspected appendicitis is placed under general anesthesia to keep the muscles completely relaxed and to keep the person unconscious. The incision is two to three inches (76 mm) long, and it is made in the right lower abdomen, several inches above the hip bone. Once the incision opens the abdomen cavity, and the appendix is identified, the surgeon removes the infected tissue and cuts the appendix from the surrounding tissue. After careful and close inspection of the infected area, and ensuring there are no signs that surrounding tissues are damaged or infected. In case of complicated appendicitis managed by an emergency open appendectomy, abdominal drainage (a temporary tube from the abdomen to the outside to avoid abscess formation) may be inserted, but this may increase the hospital stay. The surgeon will start closing the incision. This means sewing the muscles and using surgical staples or stitches to close the skin up. To prevent infections, the incision is covered with a sterile bandage or surgical adhesive.
Laparoscopic appendectomy has become an increasingly prevalent intervention for acute appendicitis since its introduction in 1983. This surgical procedure consists of making three to four incisions in the abdomen, each 0.25 to 0.5 inches (6.4 to 12.7 mm) long. This type of appendectomy is made by inserting a special surgical tool called a laparoscope into one of the incisions. The laparoscope is connected to a monitor outside the person's body, and it is designed to help the surgeon to inspect the infected area in the abdomen. The other two incisions are made for the specific removal of the appendix by using surgical instruments. Laparoscopic surgery requires general anesthesia, and it can last up to two hours. Laparoscopic appendectomy has several advantages over open appendectomy, including a shorter post-operative recovery, less post-operative pain, and lower superficial surgical site infection rate. However, the occurrence of an intra-abdominal abscess is almost three times more prevalent in laparoscopic appendectomy than open appendectomy.
The treatment begins by keeping the person who will be having surgery from eating or drinking for a given period, usually overnight. An intravenous drip is used to hydrate the person who will be having surgery. Antibiotics given intravenously such as cefuroxime and metronidazole may be administered early to help kill bacteria and thus reduce the spread of infection in the abdomen and postoperative complications in the abdomen or wound. Equivocal cases may become more difficult to assess with antibiotic treatment and benefit from serial examinations. If the stomach is empty (no food in the past six hours), general anaesthesia is usually used. Otherwise, spinal anaesthesia may be used.
Once the decision to perform an appendectomy has been made, the preparation procedure takes approximately one to two hours. Meanwhile, the surgeon will explain the surgery procedure and will present the risks that must be considered when performing an appendectomy. (With all surgeries there are risks that must be evaluated before performing the procedures.) The risks are different depending on the state of the appendix. If the appendix has not ruptured, the complication rate is only about 3% but if the appendix has ruptured, the complication rate rises to almost 59%. The most usual complications that can occur are pneumonia, hernia of the incision, thrombophlebitis, bleeding and adhesions. Evidence indicates that a delay in obtaining surgery after admission results in no measurable difference in outcomes to the person with appendicitis.
The surgeon will explain how long the recovery process should take. Abdomen hair is usually removed to avoid complications that may appear regarding the incision.
In most cases, patients going in for surgery experience nausea and vomiting that require medication before surgery. Antibiotics, along with pain medication, may be administrated before appendectomies.
Hospital lengths of stay typically range from a few hours to a few days but can be a few weeks if complications occur. The recovery process may vary depending on the severity of the condition: if the appendix had ruptured or not before surgery. Appendix surgery recovery is generally a lot faster if the appendix did not rupture. It is important that people undergoing surgery respect their doctor's advice and limit their physical activity so the tissues can heal faster. Recovery after an appendectomy may not require diet changes or a lifestyle change.
The length of hospital stays for appendicitis varies on the severity of the condition. A study from the United States found that in 2010, the average appendicitis hospital stay was 1.8 days. For stays where the person's appendix had ruptured, the average length of stay was 5.2 days.
After surgery, the patient will be transferred to a postanesthesia care unit, so his or her vital signs can be closely monitored to detect anesthesia- or surgery-related complications. Pain medication may be administered if necessary. After patients are completely awake, they are moved to a hospital room to recover. Most individuals will be offered clear liquids the day after the surgery, then progress to a regular diet when the intestines start to function correctly. Patients are recommended to sit upon the edge of the bed and walk short distances several times a day. Moving is mandatory, and pain medication may be given if necessary. Full recovery from appendectomies takes about four to six weeks but can be prolonged to up to eight weeks if the appendix had ruptured.
Most people with appendicitis recover quickly after surgical treatment, but complications can occur if treatment is delayed and if peritonitis occurs. Recovery time depends on age, condition, complications, and other circumstances, including the amount of alcohol consumption, but usually is between 10 and 28 days. For young children (around ten years old), the recovery takes three weeks.
The possibility of peritonitis is the reason why acute appendicitis warrants rapid evaluation and treatment. People with suspected appendicitis may have to undergo a medical evacuation. Appendectomies have occasionally been performed in emergency conditions (i.e., not in a proper hospital) when a timely medical evacuation was impossible.
Typical acute appendicitis responds quickly to appendectomy and occasionally will resolve spontaneously. If appendicitis resolves spontaneously, it remains controversial whether an elective interval appendectomy should be performed to prevent a recurrent episode of appendicitis. Atypical appendicitis (associated with suppurative appendicitis) is more challenging to diagnose and is more apt to be complicated even when operated early. In either condition, prompt diagnosis and appendectomy yield the best results with full recovery in two to four weeks usually. Mortality and severe complications are unusual but do occur, especially if peritonitis persists and is untreated.
Another entity known as the appendicular lump is talked about. It happens when the appendix is not removed early during infection, and omentum and intestine adhere to it, forming a palpable lump. During this period, surgery is risky unless there is pus formation evident by fever and toxicity or by USG. Medical management treats the condition.
An unusual complication of an appendectomy is "stump appendicitis": inflammation occurs in the remnant appendiceal stump left after a prior incomplete appendectomy. Stump appendicitis can occur months to years after initial appendectomy and can be identified with imaging modalities like ultrasound.
Appendicitis is most common between the ages of 5 and 40; the median age is 28. Risk factors include being male, higher household income or living in a rural area. In 2013, it resulted in 72,000 deaths globally, down from 88,000 in 1990.
In the United States, there were nearly 293,000 hospitalizations involving appendicitis in 2010. Appendicitis is one of the most frequent diagnoses for emergency department visits resulting in hospitalization among children ages 5–17 years in the United States.
- "appendicitis". Medical Dictionary. Merriam-Webster. Archived from the original on 2013-12-30.
- Graffeo CS, Counselman FL (November 1996). "Appendicitis". Emergency Medicine Clinics of North America. 14 (4): 653–71. doi:10.1016/s0733-8627(05)70273-x. PMID 8921763.
- Hobler, K. (Spring 1998). "Acute and Suppurative Appendicitis: Disease Duration and its Implications for Quality Improvement" (PDF). Permanente Medical Journal. 2 (2). Archived (PDF) from the original on 2021-03-06. Retrieved 2020-08-01.
- Paulson EK, Kalady MF, Pappas TN (January 2003). "Clinical practice. Suspected appendicitis" (PDF). The New England Journal of Medicine. 348 (3): 236–42. doi:10.1056/nejmcp013351. PMID 12529465. Archived from the original (PDF) on 2017-09-22. Retrieved 2017-11-01.
- Ferri, Fred F. (2010). Ferri's differential diagnosis : a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders (2nd ed.). Philadelphia, PA: Elsevier/Mosby. pp. Chapter A. ISBN 978-0323076999.
- Longo, Dan L.; et al., eds. (2012). Harrison's principles of internal medicine (18th ed.). New York: McGraw-Hill. pp. Chapter 300. ISBN 978-0-07174889-6. Archived from the original on 30 March 2016. Retrieved 6 November 2014.
- Varadhan KK, Neal KR, Lobo DN (April 2012). "Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials". BMJ. 344: e2156. doi:10.1136/bmj.e2156. PMC 3320713. PMID 22491789.
- GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
|author=has generic name (help)
- GBD 2015 Mortality and Causes of Death Collaborators (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
|author=has generic name (help)
- Pieper R, Kager L, Tidefeldt U (1982). "Obstruction of appendix vermiformis causing acute appendicitis. An experimental study in the rabbit". Acta Chirurgica Scandinavica. 148 (1): 63–72. PMID 7136413.
- Tintinalli, Judith E., ed. (2011). Emergency medicine : a comprehensive study guide (7th ed.). New York: McGraw-Hill. pp. Chapter 84. ISBN 978-0-07-174467-6. Archived from the original on 22 December 2016. Retrieved 6 November 2014.
- Schwartz's principles of surgery (9th ed.). New York: McGraw-Hill, Medical Pub. Division. 2010. pp. Chapter 30. ISBN 978-0-07-1547703.
- Barrett ML, Hines AL, Andrews RM (July 2013). "Trends in Rates of Perforated Appendix, 2001–2010" (PDF). Healthcare Cost and Utilization Project (HCUP) Statistical Brief #159. Rockville, MD: Agency for Healthcare Research and Quality. PMID 24199256. Archived (PDF) from the original on 2016-10-20.
- Shogilev DJ, Duus N, Odom SR, Shapiro NI (November 2014). "Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014". The Western Journal of Emergency Medicine (Review). 15 (7): 859–71. doi:10.5811/westjem.2014.9.21568. PMC 4251237. PMID 25493136.
- Mason RJ (August 2008). "Surgery for appendicitis: is it necessary?". Surgical Infections. 9 (4): 481–8. doi:10.1089/sur.2007.079. PMID 18687030.
- Fitz RH (1886). "Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment". American Journal of the Medical Sciences (92): 321–46.
- Wangensteen OH, Bowers WF (1937). "Significance of the obstructive factor in the genesis of acute appendicitis". Archives of Surgery. 34 (3): 496–526. doi:10.1001/archsurg.1937.01190090121006.
- Hollerman, J.; Bernstein, MA; Kottamasu, SR; Sirr, SA (1988). "Acute recurrent appendicitis with appendicolith". The American Journal of Emergency Medicine. 6 (6): 614–617. doi:10.1016/0735-6757(88)90105-2.
- Dehghan A, Moaddab AH, Mozafarpour S (June 2011). "An unusual localization of trichobezoar in the appendix". The Turkish Journal of Gastroenterology. 22 (3): 357–8. doi:10.4318/tjg.2011.0232. PMID 21805435.
- Jones BA, Demetriades D, Segal I, Burkitt DP (July 1985). "The prevalence of appendiceal fecaliths in patients with and without appendicitis. A comparative study from Canada and South Africa". Annals of Surgery. 202 (1): 80–2. doi:10.1097/00000658-198507000-00013. PMC 1250841. PMID 2990360.
- Nitecki S, Karmeli R, Sarr MG (September 1990). "Appendiceal calculi and fecaliths as indications for appendectomy". Surgery, Gynecology & Obstetrics. 171 (3): 185–8. PMID 2385810.
- Arnbjörnsson E (1985). "Acute appendicitis related to faecal stasis". Annales Chirurgiae et Gynaecologiae. 74 (2): 90–3. PMID 2992354.
- Raahave D, Christensen E, Moeller H, Kirkeby LT, Loud FB, Knudsen LL (February 2007). "Origin of acute appendicitis: fecal retention in colonic reservoirs: a case control study". Surgical Infections. 8 (1): 55–62. doi:10.1089/sur.2005.04250. PMID 17381397.
- Burkitt DP (September 1971). "The aetiology of appendicitis". The British Journal of Surgery. 58 (9): 695–9. doi:10.1002/bjs.1800580916. PMC 1598350. PMID 4937032.
- Segal I, Walker AR (1982). "Diverticular disease in urban Africans in South Africa". Digestion. 24 (1): 42–6. doi:10.1159/000198773. PMID 6813167.
- Arnbjörnsson E (May 1982). "Acute appendicitis as a sign of a colorectal carcinoma". Journal of Surgical Oncology. 20 (1): 17–20. doi:10.1002/jso.2930200105. PMID 7078180.
- Burkitt DP, Walker AR, Painter NS (December 1972). "Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease". Lancet. 2 (7792): 1408–12. doi:10.1016/S0140-6736(72)92974-1. PMID 4118696.
- Adamidis D, Roma-Giannikou E, Karamolegou K, Tselalidou E, Constantopoulos A (May 2000). "Fiber intake and childhood appendicitis". International Journal of Food Sciences and Nutrition. 51 (3): 153–7. doi:10.1080/09637480050029647. PMID 10945110.
- Hugh TB, Hugh TJ (July 2001). "Appendicectomy--becoming a rare event?". The Medical Journal of Australia. 175 (1): 7–8. PMID 11476215. Archived from the original on 2006-08-26.
- Gear JS, Brodribb AJ, Ware A, Mann JI (January 1981). "Fibre and bowel transit times". The British Journal of Nutrition. 45 (1): 77–82. doi:10.1079/BJN19810078. PMID 6258626.
- Ashdown HF, D'Souza N, Karim D, Stevens RJ, Huang A, Harnden A (December 2012). "Pain over speed bumps in diagnosis of acute appendicitis: diagnostic accuracy study". BMJ. 345 (dec14 14): e8012. doi:10.1136/bmj.e8012. PMC 3524367. PMID 23247977.
- Sachdeva, Anupam; Dutta, AK (31 August 2012). Advances in Pediatrics. JP Medical. p. 1432. ISBN 9789350257777.
- Small, V (2008). Dolan, B; Holt, L (eds.). Surgical emergencies. Accident and Emergency: Theory into Practice (2nd ed.). Elsevier.[page needed]
- Virgilio, Christian de; Frank, Paul N.; Grigorian, Areg (10 January 2015). Surgery. Springer. p. 215. ISBN 9781493917266.
- Kadim, Abbas Abdul Mahdi (1 April 2016). "Surgical and Clinical Review of Acute Appendicitis" (PDF). International Journal of Multidisciplinary and Current Research. 4. ISSN 2321-3124. Archived (PDF) from the original on 9 August 2016.
Massouh sign characterized by increased abdominal pain with coughing. It may be an indicator of appendicitis. A positive Massouh sign is a grimace of the person being examined upon a right sided (and not left) sweep (40).
- Wolfson, Allan B.; Cloutier, Robert L.; Hendey, Gregory W.; Ling, Louis J.; Schaider, Jeffrey J.; Rosen, Carlo L. (27 October 2014). Harwood-Nuss' Clinical Practice of Emergency Medicine. Wolters Kluwer Health. p. 5810. ISBN 9781469889481. Archived from the original on 10 September 2017. Retrieved 15 June 2016.
Physical signs classically associated with acute appendicitis include Rovsing sign, psoas sign, and obturator sign.
- Rovsing, N.T. (1907). "Indirektes Hervorrufen des typischen Schmerzes an McBurney's Punkt. Ein Beitrag zur diagnostik der Appendicitis und Typhlitis". Zentralblatt für Chirurgie (in Deutsch). Leipzig. 34: 1257–1259.
- Dunster, Edward Swift; Hunter, James Bradbridge; Sajous, Charles Euchariste de Medicis; Foster, Frank Pierce; Stragnell, Gregory; Klaunberg, Henry J.; Martí-Ibáñez, Félix (1922). International Record of Medicine and General Practice Clinics. New York Medical Journal. p. 663.
- Gregory, Charmaine (2010). "Appendicitis". CDEM Self Study Modules. Clerkship Directors in Emergency Medicine. Archived from the original on 2013-11-30.
- Bundy DG, Byerley JS, Liles EA, Perrin EM, Katznelson J, Rice HE (July 2007). "Does this child have appendicitis?". JAMA. 298 (4): 438–51. doi:10.1001/jama.298.4.438. PMC 2703737. PMID 17652298.
- American College of Radiology, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation, American College of Radiology, archived (PDF) from the original on April 16, 2012, retrieved August 17, 2012
- Krishnamoorthi R, Ramarajan N, Wang NE, Newman B, Rubesova E, Mueller CM, Barth RA (April 2011). "Effectiveness of a staged US and CT protocol for the diagnosis of pediatric appendicitis: reducing radiation exposure in the age of ALARA". Radiology. 259 (1): 231–9. doi:10.1148/radiol.10100984. PMID 21324843.
- Wan MJ, Krahn M, Ungar WJ, Caku E, Sung L, Medina LS, Doria AS (February 2009). "Acute appendicitis in young children: cost-effectiveness of US versus CT in diagnosis--a Markov decision analytic model". Radiology. 250 (2): 378–86. doi:10.1148/radiol.2502080100. PMID 19098225.
- Terasawa T, Blackmore CC, Bent S, Kohlwes RJ (October 2004). "Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents". Annals of Internal Medicine. 141 (7): 537–46. doi:10.7326/0003-4819-141-7-200410050-00011. PMID 15466771.
- Reddan T, Corness J, Mengersen K, Harden F (March 2016). "Ultrasound of paediatric appendicitis and its secondary sonographic signs: providing a more meaningful finding". Journal of Medical Radiation Sciences. 63 (1): 59–66. doi:10.1002/jmrs.154. PMC 4775827. PMID 27087976.
- Reddan T, Corness J, Mengersen K, Harden F (June 2016). "Sonographic diagnosis of acute appendicitis in children: a 3-year retrospective". Sonography. 3 (3): 87–94. doi:10.1002/sono.12068.
- Lee, Sun Hwa; Yun, Seong Jong (April 2019). "Diagnostic performance of emergency physician-performed point-of-care ultrasonography for acute appendicitis: A meta-analysis". The American Journal of Emergency Medicine. 37 (4): 696–705. doi:10.1016/j.ajem.2018.07.025. PMID 30017693.
- "UOTW #45 - Ultrasound of the Week". Ultrasound of the Week. 25 April 2015. Archived from the original on 9 May 2017.
- Kim Y, Kang G, Moon SB (November 2014). "Increasing utilization of abdominal CT in the Emergency Department of a secondary care center: does it produce better outcomes in caring for pediatric surgical patients?". Annals of Surgical Treatment and Research. 87 (5): 239–44. doi:10.4174/astr.2014.87.5.239. PMC 4217253. PMID 25368849.
- Liu B, Ramalho M, AlObaidy M, Busireddy KK, Altun E, Kalubowila J, Semelka RC (August 2014). "Gastrointestinal imaging-practical magnetic resonance imaging approach". World Journal of Radiology. 6 (8): 544–66. doi:10.4329/wjr.v6.i8.544. PMC 4147436. PMID 25170393.
- Garcia K, Hernanz-Schulman M, Bennett DL, Morrow SE, Yu C, Kan JH (February 2009). "Suspected appendicitis in children: diagnostic importance of normal abdominopelvic CT findings with nonvisualized appendix". Radiology. 250 (2): 531–7. doi:10.1148/radiol.2502080624. PMID 19188320.
- Doria AS, Moineddin R, Kellenberger CJ, Epelman M, Beyene J, Schuh S, Babyn PS, Dick PT (October 2006). "US or CT for Diagnosis of Appendicitis in Children and Adults? A Meta-Analysis". Radiology. 241 (1): 83–94. doi:10.1148/radiol.2411050913. PMID 16928974.
- Burke LM, Bashir MR, Miller FH, Siegelman ES, Brown M, Alobaidy M, Jaffe TA, Hussain SM, Palmer SL, Garon BL, Oto A, Reinhold C, Ascher SM, Demulder DK, Thomas S, Best S, Borer J, Zhao K, Pinel-Giroux F, De Oliveira I, Resende D, Semelka RC (November 2015). "Magnetic resonance imaging of acute appendicitis in pregnancy: a 5-year multi-institutional study". American Journal of Obstetrics and Gynecology. 213 (5): 693.e1–6. doi:10.1016/j.ajog.2015.07.026. PMID 26215327.
- Rao PM, Rhea JT, Rao JA, Conn AK (July 1999). "Plain abdominal radiography in clinically suspected appendicitis: diagnostic yield, resource use, and comparison with CT". The American Journal of Emergency Medicine. 17 (4): 325–8. doi:10.1016/S0735-6757(99)90077-3. PMID 10452424.
- Boleslawski E, Panis Y, Benoist S, Denet C, Mariani P, Valleur P (March 1999). "Plain abdominal radiography as a routine procedure for acute abdominal pain of the right lower quadrant: prospective evaluation". World Journal of Surgery. 23 (3): 262–4. doi:10.1007/pl00013181. PMID 9933697.
- APPENDICITIS from Townsend: Sabiston Textbook of Surgery on MD Consult Archived December 3, 2013, at the Wayback Machine
- Kulik DM, Uleryk EM, Maguire JL (January 2013). "Does this child have appendicitis? A systematic review of clinical prediction rules for children with acute abdominal pain". Journal of Clinical Epidemiology. 66 (1): 95–104. doi:10.1016/j.jclinepi.2012.09.004. PMID 23177898.
- Abd Al-Fatah, Mohamed (2017). "Importance of histopathological evaluation of appendectomy specimens". Al-Azhar Assiut Medical Journal. 15 (2): 97. doi:10.4103/AZMJ.AZMJ_19_17. ISSN 1687-1693.
- Lee, Won-Suk; Choi, Sang Tae; Lee, Jung Nam; Kim, Keon Kug; Park, Yeon Ho; Baek, Jeong Heum (2011). "A retrospective clinicopathological analysis of appendiceal tumors from 3,744 appendectomies: a single-institution study". International Journal of Colorectal Disease. 26 (5): 617–621. doi:10.1007/s00384-010-1124-1. ISSN 0179-1958.
- Fink AS, Kosakowski CA, Hiatt JR, Cochran AJ (June 1990). "Periappendicitis is a significant clinical finding". American Journal of Surgery. 159 (6): 564–8. doi:10.1016/S0002-9610(06)80067-X. PMID 2349982.
- Carr, Norman J. (2000). "The pathology of acute appendicitis". Annals of Diagnostic Pathology. 4 (1): 46–58. doi:10.1016/S1092-9134(00)90011-X. ISSN 1092-9134.
- "Pelvic inflammatory disease (PID) Symptoms; Diseases and Conditions". Mayo Clinic. Archived from the original on 2015-05-07. Retrieved 2015-04-23.
- Cunha BA, Pherez FM, Durie N (July 2010). "Swine influenza (H1N1) and acute appendicitis". Heart & Lung. 39 (6): 544–6. doi:10.1016/j.hrtlng.2010.04.004. PMID 20633930.
- Zheng H, Sun Y, Lin S, Mao Z, Jiang B (August 2008). Yersinia enterocolitica infection in diarrheal patients. Eur. J. Clin. Microbiol. Infect. Dis. Vol. 27. pp. 741–52. doi:10.1007/s10096-008-0562-y. ISBN 978-0-9600805-6-4. PMID 18575909.
- Sallinen V, Akl EA, You JJ, Agarwal A, Shoucair S, Vandvik PO, Agoritsas T, Heels-Ansdell D, Guyatt GH, Tikkinen KA (May 2016). "Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis". The British Journal of Surgery. 103 (6): 656–667. doi:10.1002/bjs.10147. PMC 5069642. PMID 26990957.
- Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, Ulrich A, Büchler MW, Diener MK (May 2017). "Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials (PROSPERO 2015: CRD42015016882)". Annals of Surgery. 265 (5): 889–900. doi:10.1097/SLA.0000000000002039. PMID 27759621.
- Huang L, Yin Y, Yang L, Wang C, Li Y, Zhou Z (May 2017). "Comparison of Antibiotic Therapy and Appendectomy for Acute Uncomplicated Appendicitis in Children: A Meta-analysis". JAMA Pediatrics. 171 (5): 426–434. doi:10.1001/jamapediatrics.2017.0057. PMC 5470362. PMID 28346589.
- Wilms IM, de Hoog DE, de Visser DC, Janzing HM (November 2011). "Appendectomy versus antibiotic treatment for acute appendicitis". The Cochrane Database of Systematic Reviews (11): CD008359. doi:10.1002/14651858.CD008359.pub2. PMID 22071846.
- Georgiou R, Eaton S, Stanton MP, Pierro A, Hall NJ (March 2017). "Efficacy and Safety of Nonoperative Treatment for Acute Appendicitis: A Meta-analysis" (PDF). Pediatrics. 139 (3): e20163003. doi:10.1542/peds.2016-3003. PMID 28213607. Archived (PDF) from the original on 2019-04-27. Retrieved 2020-08-01.
- Andersen BR, Kallehave FL, Andersen HK (July 2005). "Antibiotics versus placebo for prevention of postoperative infection after appendicectomy". The Cochrane Database of Systematic Reviews (3): CD001439. doi:10.1002/14651858.CD001439.pub2. PMID 16034862.
- Anderson M, Collins E (November 2008). "Analgesia for children with acute abdominal pain and diagnostic accuracy". Archives of Disease in Childhood. 93 (11): 995–7. doi:10.1136/adc.2008.137174. PMID 18305071. Archived from the original on 2013-05-17.
- Jaschinski T, Mosch CG, Eikermann M, Neugebauer EA, Sauerland S (November 2018). "Laparoscopic versus open surgery for suspected appendicitis". The Cochrane Database of Systematic Reviews. 11: CD001546. doi:10.1002/14651858.CD001546.pub4. PMC 6517145. PMID 30484855.
- Berry J, Malt RA (November 1984). "Appendicitis near its centenary". Annals of Surgery. 200 (5): 567–75. doi:10.1097/00000658-198411000-00002. PMC 1250537. PMID 6385879.
- "Appendicitis". National Institute of Diabetes and Digestive and Kidney Diseases. U.S Department of Health and Human Services. Archived from the original on 2010-02-01. Retrieved 2010-02-01.
- Li Z, Zhao L, Cheng Y, Cheng N, Deng Y (May 2018). "Abdominal drainage to prevent intra-peritoneal abscess after open appendectomy for complicated appendicitis". The Cochrane Database of Systematic Reviews. 5 (5): CD010168. doi:10.1002/14651858.CD010168.pub3. PMC 6494575. PMID 29741752.
- Semm K (March 1983). "Endoscopic appendectomy". Endoscopy. 15 (2): 59–64. doi:10.1055/s-2007-1021466. PMID 6221925.
- Siewert B, Raptopoulos V, Liu SI, Hodin RA, Davis RB, Rosen MP (November 2003). "CT predictors of failed laparoscopic appendectomy". Radiology. 229 (2): 415–20. doi:10.1148/radiol.2292020825. PMID 14595145.
- "Appendicitis". Encyclopedia of Surgery. Archived from the original on 2010-02-09. Retrieved 2010-02-01.
- "'Emergency' appendix surgery can wait: MDs". CBC News. 2010-09-21. Archived from the original on 2016-06-30.
- Ingraham AM, Cohen ME, Bilimoria KY, Ko CY, Hall BL, Russell TR, Nathens AB (September 2010). "Effect of delay to operation on outcomes in adults with acute appendicitis". Archives of Surgery. 145 (9): 886–92. doi:10.1001/archsurg.2010.184. PMID 20855760.
Delay of appendectomy for acute appendicitis in adults does not appear to adversely affect 30-day outcomes.
- Appendicitis surgery, removal and recovery Retrieved on 2010-02-01 Archived January 11, 2010, at the Wayback Machine
- Liang MK, Lo HG, Marks JL (February 2006). "Stump appendicitis: a comprehensive review of literature". The American Surgeon. 72 (2): 162–6. PMID 16536249.
- Reddan T, Corness J, Powell J, Harden F, Mengersen K (2016). "Stumped? It could be stump appendicitis". Sonography. 4: 36–39. doi:10.1002/sono.12098.
- "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 11 November 2009. Retrieved Nov 11, 2009.
- Ellis H (March 2012). "Acute appendicitis". British Journal of Hospital Medicine. 73 (3): C46-8. doi:10.12968/hmed.2012.73.sup3.C46. PMID 22411604.
- "Appendicitis". VoxHealth.co. Archived from the original on 2016-06-29. Retrieved 2016-06-16.
- GBD 2013 Mortality Causes of Death Collaborators (January 2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442.
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- Wier, Lauren M.; Yu, Hao; Owens, Pamela L.; Washington, Raynard (June 2013). Overview of Children in the Emergency Department, 2010. Healthcare Cost and Utilization Project Statistical Brief #157 (Report). Agency for Healthcare Research and Quality. Archived from the original on 2013-12-03.
- Appendicitis at Curlie
- CT of the abdomen showing acute appendicitis Archived 2021-02-24 at the Wayback Machine
- Appendicitis, history, diagnosis and treatment by Surgeons Net Education
- Appendicitis: Acute Abdomen and Surgical Gastroenterology Archived 2010-10-24 at the Wayback Machine from the Merck Manual Professional (content last modified September 2007)