Masoprocol

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Masoprocol
Masoprocol.svg
Clinical data
Trade namesActinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Topical
ATC code
Pharmacokinetic data
BioavailabilityVery low
Identifiers
  • 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.172 Edit this at Wikidata
Chemical and physical data
FormulaC18H22O4
Molar mass302.370 g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
  • InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ checkY
  • Key:HCZKYJDFEPMADG-TXEJJXNPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References

  1. ^ Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

External links