|AHFS/Drugs.com||Consumer Drug Information|
|Elimination half-life||21.5 days (mean)|
|Chemical and physical data|
|Formula||C68H74N8O11 (for n=0)|
|Molar mass||1179.36 g/mol (for n=0) g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units. In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.
Approvals and indications
It was approved in Canada in 1993 for the treatment of bladder cancer. It was approved in Japan in 1994 (for early stage lung cancer?). It was approved by the U.S. FDA in December 1995 for esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer.
- "Porfimer injection Prescribing information" (PDF).
- Usuda J, Kato H, Okunaka T, Furukawa K, Tsutsui H, Yamada K, et al. (June 2006). "Photodynamic therapy (PDT) for lung cancers". Journal of Thoracic Oncology. 1 (5): 489–93. doi:10.1016/S1556-0864(15)31616-6. PMID 17409904.
- "FDA Patient Safety News: Show #20, October 2003". October 2003. Retrieved 2009-08-17.