Pegaspargase

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Pegaspargase
Pegaspargasa.png
Names
Pronunciation/pəˈɡæspərɡz/
Trade namesOncaspar
  • Pegylated E. coli L-asparagine amidohydrolase
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
use
Intramuscular injection (IM), intravenous (IV)
Defined daily doseNot established[1]
External links
AHFS/Drugs.comMonograph
MedlinePlusa695031
Legal
License data
Legal status
Chemical and physical data
FormulaC1377H2208N382O442S17
Molar mass31732.06 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Pegaspargase, sold under the trade name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL).[2] Often it is used together with anthracycline, vincristine, and prednisone.[3] It is used by injection.[3]

Common side effects include allergic reactions, blood clotting problems, high blood sugar, liver problems, pancreas inflammation, and blood clots in the brain.[3] Its use during pregnancy may harm the baby.[4] It is a modified version of the enzyme asparaginase which has undergone PEGylation.[5][3] It works by breaking down asparagine, decreasing its availability to make protein.[3]

Pegaspargase was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[6] It is made by Sigma-Tau.[3] In the United States it costs about $US17,800 per 3,750 units vial.[7]

Dosage

The defined daily dose is not established.[1]

References

  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 9 September 2020. CS1 maint: discouraged parameter (link)
  2. Graham ML (2003). "Pegaspargase: a review of clinical studies". Adv. Drug Deliv. Rev. 55 (10): 1293–302. doi:10.1016/S0169-409X(03)00110-8. PMID 14499708.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 "Pegaspargase Monograph for Professionals". Drugs.com. Retrieved 11 October 2019. CS1 maint: discouraged parameter (link)
  4. "Pegaspargase (Oncaspar) Use During Pregnancy". Drugs.com. Retrieved 11 October 2019. CS1 maint: discouraged parameter (link)
  5. "UNM Cancer Center". Archived from the original on 3 September 2006. Retrieved 28 August 2007. CS1 maint: discouraged parameter (link)
  6. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. "Oncaspar Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 11 October 2019. CS1 maint: discouraged parameter (link)

External links

External sites:
Identifiers: