Idarubicin

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Idarubicin
Idarubicin.svg
Idarubicin ball-and-stick.png
Names
Pronunciation/ˌdəˈrbɪsɪn/
Trade namesZavedos, Idamycin, others
Other namesIdarubicin hydrochloride, 4-demethoxydaunorubicin, 9-acetyl-7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione
  • (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxo-α-L-lyxo-hexopyranoside
Clinical data
Drug classAnthracycline[1]
Main usesAcute myeloid leukemia (AML), breast cancer[2][3]
Side effectsNausea, hair loss, abdominal pain, diarrhea, bleeding, mouth inflammation, fever, headache[2]
Pregnancy
category
  • US: D (Evidence of risk)
External links
AHFS/Drugs.comMonograph
US NLMIdarubicin
MedlinePlusa691004
Legal
Legal status
Pharmacokinetics
Protein binding97%
Elimination half-life22 hours
Chemical and physical data
FormulaC26H27NO9
Molar mass497.500 g·mol−1
3D model (JSmol)
  • O=C2c1c(O)c5c(c(O)c1C(=O)c3ccccc23)C[C@@](O)(C(=O)C)C[C@@H]5O[C@@H]4O[C@H]([C@@H](O)[C@@H](N)C4)C
  • InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1 checkY
  • Key:XDXDZDZNSLXDNA-TZNDIEGXSA-N checkY
  (verify)

Idarubicin, sold under the brand name Zavedos and Idamycin, is a medication used to treat acute myeloid leukemia (AML) and breast cancer.[2][3] It is often used with cytarabine.[2] It is given by injection into a vein or taken by mouth.[2][3]

Common side effects include nausea, hair loss, abdominal pain, diarrhea, bleeding, mouth inflammation, fever, and headache.[2] Other side effects may include heart failure, arrhythmias, bone marrow suppression, high uric acid, liver problems, kidney problems.[2] Use in pregnancy may harm the baby.[2] It is an anthracycline and acts similar to daunorubicin.[1]

Idarubicin was approved for medical use in the United States in 1990.[2] In the United Kingdom 10 mg for injection costs the NHS about £175 as of 2021.[3] In the United States this amount costs about 70 USD.[4]

Medical use

Dosage

The typical dose is 12 to 45 mg/m2 body surface area though different doses may be used in those with liver or kidney problems.[1][3]

Side effects

Diarrhea, stomach cramps, nausea and vomiting are common among patients treated with idarubicin.[5]

References

  1. 1.0 1.1 1.2 "Doxorubicin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Retrieved 25 November 2021.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 "IDArubicin Monograph for Professionals". Drugs.com. Retrieved 25 November 2021.
  3. 3.0 3.1 3.2 3.3 3.4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 948. ISBN 978-0857114105.
  4. "Idarubicin Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 25 November 2021.
  5. "Idarubicin Side Effects: Common, Severe, Long Term". Drugs.com. Retrieved 2019-06-21.

External links

Identifiers: