|Trade names||Arranon, Atriance|
|Main uses||Acute T-cell lymphoblastic leukemia and lymphoma|
|Side effects||Bone marrow suppression, sleepiness, headache, numbness, fever, swelling, vomiting|
|Metabolism||By adenosine deaminase, to 9-β-D-arabinofuranosylguanine|
|Elimination half-life||30 minutes (nelarabine)|
3 hours (ara-G)
|Chemical and physical data|
|Molar mass||297.271 g·mol−1|
|3D model (JSmol)|
Nelarabine, sold under the brand names Arranon and Atriance , is a medication used to treat T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It is used when other treatments are not effective. It is given by gradual injection into a vein.
Common side effects include bone marrow suppression, sleepiness, headache, numbness, fever, swelling, and vomiting. Other side effects may include confusion, seizures, tumor lysis syndrome, and peripheral neuropathy. Use in pregnancy may harm the baby. It is an antimetabolite which replaces guanine and interferes with the making of new DNA.
Nelarabine was approved for medical use in the United States and Europe in 2005. In the United Kingdom six vials of 250 mg cost the NHS about £1,300 as of 2021. In the United States this amount costs about 4,600 USD. A generic version was approved in 2021 in the USA.
In adults it is used at a dose of 1500 mg/m2 on day 1, 3, and 5 out of 21 days.
- "Atriance". Archived from the original on 12 November 2020. Retrieved 12 November 2021.
- "Nelarabine Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 12 November 2021.
- "Atriance EPAR". European Medicines Agency (EMA). Archived from the original on 12 November 2020. Retrieved 4 December 2020.
- "Arranon- nelarabine injection". DailyMed. 11 June 2020. Archived from the original on 17 October 2020. Retrieved 4 December 2020.
- "DailyMed - ARRANON- nelarabine injection". dailymed.nlm.nih.gov. Archived from the original on 17 October 2020. Retrieved 12 November 2021.
- BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 960. ISBN 978-0857114105.
- "Arranon Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 November 2021.
- Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA. Archived from the original on 21 June 2022. Retrieved 22 October 2022.