Nelarabine

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Nelarabine
Nelarabine structure.svg
Nelarabine ball-and-stick.png
Names
Trade namesArranon, Atriance
Other names506U78
Clinical data
Drug classAntimetabolite[1]
Main usesAcute T-cell lymphoblastic leukemia and lymphoma[2]
Side effectsBone marrow suppression, sleepiness, headache, numbness, fever, swelling, vomiting[2]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
Intravenous
External links
AHFS/Drugs.comMonograph
US NLMNelarabine
MedlinePlusa607077
Legal
License data
Legal status
Pharmacokinetics
Protein binding<25%
MetabolismBy adenosine deaminase, to 9-β-D-arabinofuranosylguanine
Elimination half-life30 minutes (nelarabine)
3 hours (ara-G)
ExcretionKidney
Chemical and physical data
FormulaC11H15N5O5
Molar mass297.271 g·mol−1
3D model (JSmol)
  • n2c1c(nc(nc1OC)N)n(c2)[C@@H]3O[C@@H]([C@@H](O)[C@@H]3O)CO
  • InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1 checkY
  • Key:IXOXBSCIXZEQEQ-UHTZMRCNSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Nelarabine, sold under the brand names Arranon and Atriance , is a medication used to treat T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).[2] It is used when other treatments are not effective.[2] It is given by gradual injection into a vein.[2]

Common side effects include bone marrow suppression, sleepiness, headache, numbness, fever, swelling, and vomiting.[2] Other side effects may include confusion, seizures, tumor lysis syndrome, and peripheral neuropathy.[2] Use in pregnancy may harm the baby.[2] It is an antimetabolite which replaces guanine and interferes with the making of new DNA.[1]

Nelarabine was approved for medical use in the United States and Europe in 2005.[5][1] In the United Kingdom six vials of 250 mg cost the NHS about £1,300 as of 2021.[6] In the United States this amount costs about 4,600 USD.[7]

Medical uses

Dosage

In adults it is used at a dose of 1500 mg/m2 on day 1, 3, and 5 out of 21 days.[5]

References

  1. 1.0 1.1 1.2 "Atriance". Retrieved 12 November 2021.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 "Nelarabine Monograph for Professionals". Drugs.com. Retrieved 12 November 2021.
  3. "Arranon- nelarabine injection". DailyMed. 11 June 2020. Retrieved 4 December 2020.
  4. "Atriance EPAR". European Medicines Agency (EMA). Retrieved 4 December 2020.
  5. 5.0 5.1 "DailyMed - ARRANON- nelarabine injection". dailymed.nlm.nih.gov. Retrieved 12 November 2021.
  6. BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 960. ISBN 978-0857114105.
  7. "Arranon Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 November 2021.

External links

External sites:
Identifiers: