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The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa.

There are three ureidopenicillins in clinical use:[1]

They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.

They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria.


  1. ^ "Mayo Clinic Proceedings". Retrieved 2008-12-26.[dead link]