|Chemical and physical data|
|Molar mass||349.77 g·mol−1|
|3D model (JSmol)|
Loracarbef is an antibiotic.
It is in the second-generation cephalosporin family of medications.
It is a carbacephem. Loracarbef is a synthetic "carba" analog of cefaclor, and is more stable.
Loracarbef received FDA approval in 1991 and it was marketed under the trade name Lorabid. Its use was discontinued in 2006.
Usage & Indications
Loracarbef was used to treat infections of the lungs, maxillary sinuses, throat, skin, and urinary tract.
Spectrum of Activity
Loracarbef had broad spectrum effectiveness against both gram-negative and gram-positive bacteria, including those precipitating infections of the respiratory tract, sinuses, tonsils, skin, urinary tract, and kidneys. It was of specific use in those infections caused by E. Coli, S. pyogenes, S. Aureus, S. saprphyticus, S. penumoniae, H. influenza, and M. catarrhalis. 
Diarrhea is the most common adverse effect with loracarbef. Side effects are more frequently seen with children under the age of twelve.
- ↑ Biedenbach DJ, Jones RN (February 1994). "Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef". Journal of Clinical Microbiology. 32 (2): 559–62. doi:10.1128/JCM.32.2.559-562.1994. PMC 263078. PMID 8150976.
- ↑ Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 832. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-30.
- ↑ "Lorabid (Loracarbef): Uses, Dosage, Side Effects, Interactions, Warning". RxList. Archived from the original on 2018-01-16. Retrieved 2020-06-15.
- ↑ "Loracarbef". www.drugbank.ca. Archived from the original on 2019-06-16. Retrieved 2020-06-15.
- Pages using duplicate arguments in template calls
- Articles with changed EBI identifier
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- All articles with unsourced statements
- Articles with unsourced statements from January 2011
- Articles with invalid date parameter in template
- All stub articles
- Antibiotic stubs
- Cephalosporin antibiotics