Spesolimab

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Spesolimab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetInterleukin 36 receptor (IL1RL2/IL1RAP)
Names
Trade namesSpevigo
Other namesBI-655130, spesolimab-sbzo
Clinical data
Main usesGeneralized pustular psoriasis (GPP)[1]
Side effectsTiredness, nausea, headache, itchiness, bruising at the site of administration, urinary tract infection[1]
Routes of
use		Intravenous
Typical dose900 mg[1]
External links
AHFS/Drugs.comMonograph
Legal
License data
Legal status
Chemical and physical data
FormulaC6480H9988N1736O2012S46
Molar mass145880.08 g·mol−1

Spesolimab, sold under the brand name Spevigo, is a medication used to treat a flair of generalized pustular psoriasis (GPP).[1] It is given by gradual injection into a vein.[1]

Common side effects include tiredness, nausea, headache, itchiness, bruising at the site of administration, and urinary tract infection.[1] Other side effects may include infection, allergic reactions, and infusion reactions.[1] It is a monoclonal antibody that blocks interleukin-36 receptor (IL1RL2/IL1RAP).[1][2]

Spesolimab was approved for medical use in the United States in 2022.[1] It is recommended for approval in Europe but is not in the approval process in the United Kingdom as of 2022.[3] In the United States it costs about 54,000 USD per dose as of 2022.[4]

Medical uses

Dosage

It is generally given as a dose of 900 mg, which may be repeated after 1 week.[1]

Society and culture

Legal status

On 13 October 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a conditional marketing authorization for the medicinal product Spevigo, intended for the treatment of flares in adult patients with generalised pustular psoriasis.[5] The applicant for this medicinal product is Boehringer Ingelheim International GmbH.[5]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 "Spevigo- spesolimab-sbzo injection". DailyMed. 1 September 2022. Archived from the original on 16 October 2022. Retrieved 16 October 2022.
  2. ↑ Ratnarajah K, Jfri A, Litvinov IV, Netchiporouk E (2020). "Spesolimab: A Novel Treatment for Pustular Psoriasis". Journal of Cutaneous Medicine and Surgery. 24 (2): 199–200. doi:10.1177/1203475419888862. PMID 32208020. S2CID 214641620.
  3. ↑ "Spesolimab". SPS - Specialist Pharmacy Service. 3 May 2019. Archived from the original on 17 May 2022. Retrieved 13 December 2022.
  4. ↑ "Spevigo Prices, Coupons, Copay & Patient Assistance". Drugs.com. Retrieved 13 December 2022.
  5. ↑ 5.0 5.1 "Spevigo: Pending EC decision". European Medicines Agency. 14 October 2022. Archived from the original on 15 October 2022. Retrieved 15 October 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

External links

External sites:
Identifiers:
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