|Target||thymic stromal lymphopoietin (TSLP)|
|Other names||MEDI9929, AMG 157, tezepelumab-ekko|
|Side effects||Joint pain, sore throat|
|Typical dose||210 mg|
|Chemical and physical data|
|Molar mass||144590.40 g·mol−1|
Tezepelumab, sold under the brand name Tezspire, is a medication used for the treatment of asthma. Specifically it is used for severe asthma, which is not controlled by other medication, in those at least 12 years old. It is given by injection under the skin every 4 weeks.
The most common side effects include joint pain and sore throat. Other side effects may include allergic reactions. While there is no evidence of harm in pregnancy, such use has not been well studied. It is a monoclonal antibody that blocks thymic stromal lymphopoietin (TSLP), resulting in less airway inflammation.
Tezepelumab was approved for medical use in the United States in 2021 and Europe in 2022. In the United States it costs about 48,000 USD per year as of 2022. While approved in the UK it was not yet marketed as of 2022.
The typical dose is 210 mg every 4 weeks.
Two main studies including over 1,500 adults and adolescents with inadequately controlled asthma showed that tezepelumab was effective in reducing the number of severe asthma flare‑ups.
Society and culture
On 21 July 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Tezspire, intended as add-on treatment in adult and adolescent patients with severe asthma. The applicant for this medicinal product is AstraZeneca AB. Tezepelumab was approved for medical use in the European Union in September 2022.
It is being studied for the treatment of chronic obstructive pulmonary disease, chronic rhinosinusitis with nasal polyps, chronic spontaneous urticaria and eosinophilic esophagitis (EoE).
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