|Drug class||Monoclonal antibody|
|Main uses||Psoriasis, ankylosing spondylitis, psoriatic arthritis|
|Side effects||Runny nose, diarrhea, cold sores, hives|
|Chemical and physical data|
|Molar mass||147944.37 g·mol−1|
|(what is this?)|
Common side effects include a runny nose, diarrhea, cold sores, and hives. Other side effects may include anaphylaxis and infection. Use during pregnancy or breastfeeding is not recommended. It is a monoclonal antibody that binds to and inhibits interleukin (IL)-17A.
Secukinumab was approved for medical use in the United States and Europe in 2015. In the United Kingdom 150 mg costs the NHS about £600 as of 2021. This amount in the United States costs about 6,200 USD.
Secukinumab is used to treat psoriasis, ankylosing spondylitis, and psoriatic arthritis. It is given by subcutaneous injection and is sold in a pre-filled syringe or autoinjector that can be used at home and as a lyophilized powder for use in hospitals and clinics.
Secukinumab was not tested in pregnant women; animal studies did not show harm at relevant doses. The US Food and Drug Administration advises that the drug should be used in pregnant women only if the risk to the fetus is justified by the potential benefit; the European Medicines Agency (EMA) advises that women should not become pregnant while taking it.
In the European Union, secukinumab is indicated for the treatment of:
- moderate to severe plaque psoriasis in adults, children and adolescents from the age of six years who are candidates for systemic therapy.
- active psoriatic arthritis in adults, alone or in combination with methotrexate (MTX), when the response to previous disease modifying anti rheumatic drug (DMARD) therapy has been inadequate.
- active ankylosing spondylitis in adults who have responded inadequately to conventional therapy.
- active non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence in adults who have responded inadequately to non steroidal anti inflammatory drugs (NSAIDs).
Very common (greater than 10% of people experience them) adverse effects include upper respiratory tract infections.
Common (between 1% and 10% of people experience them) include oral herpes, runny nose, and diarrhea.
In clinical trials there were rare instances of hypersensitivity reactions, severe infections, and some cases of serious inflammatory bowel disease, some of which were new and some of which were exacerbations of existing conditions. Caution should be used when starting secukinumab in patients with inflammatory bowel disease, and patients being treated with secukinumab should be monitored for signs and symptoms of inflammatory bowel disease.
Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor which is expressed in various types of cells, including keratinocytes in skin.
In January 2015, secukinumab was approved in the United States and in the European Union to treat adults with moderate-to-severe plaque psoriasis. It was the first IL17A inhibiting drug ever approved. In January 2016, the FDA approved it to treat adults with ankylosing spondylitis, and psoriatic arthritis and in February 2018 a label update was approved to include the treatment for moderate-to-severe scalp psoriasis.
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