Basiliximab

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Basiliximab
Monoclonal antibody
TypeWhole antibody
SourceChimeric (mouse/human)
TargetCD25
Names
Trade namesSimulect
Clinical data
Main usesKidney transplant[1]
Side effectsConstipation, nausea, abdominal pain, heart burn, high potassium, low potassium, headache, swelling, fever, shortness of breath, trouble sleeping[1]
Pregnancy
category
  • AU: D
  • US: B (No risk in non-human studies)
External links
AHFS/Drugs.comMonograph
US NLMBasiliximab
Legal
License data
Pharmacokinetics
Elimination half-life7.2 days
Chemical and physical data
FormulaC6378H9844N1698O1997S48
Molar mass143801.68 g·mol−1
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Basiliximab, sold under the brand name Simulect, is a medication used to prevent rejection following a kidney transplant.[1] It is used together with ciclosporin and corticosteroids.[2] It is given by injection into a vein.[2]

Common side effects include constipation, nausea, abdominal pain, heart burn, high potassium, low potassium, headache, swelling, fever, shortness of breath, and trouble sleeping.[1] Other side effects may include infections and anaphylaxis.[1] Use in pregnancy is not recommended.[2] It is a monoclonal antibody that attaches to CD25 on T cells and thus blocks interleukin-2.[3]

Basiliximab was approved for medical use in the United States and Europe in 1998.[1][3] In the United Kingdom a typical dose costs about £840 as of 2021.[2] In the United States this amount costs about 4,100 USD.[4]

Medical uses

Basiliximab is an immunosuppressant agent used to prevent immediate transplant rejection in people who are receiving kidney transplants, in combination with other agents.[5] It has been reported that some cases of lichen planus have been successfully treated with basiliximab as an alternative therapy to cyclosporin. No short-term side effects have been reported.[6]

Dosage

It is given as a dose of 20 mg within two hours of surgery followed by 20 mg 4 days later.[2]

Mechanism of action

Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of antibodies, which would bind to the transplanted organ and stimulate an immune response against the transplant.[7][8]

Chemistry

It is a chimeric CD25 monoclonal antibody of the IgG1 isotype.[7][8]

History

It is a Novartis product and was approved by the Food and Drug Administration (FDA) in 1998.[9]

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Basiliximab Monograph for Professionals". Drugs.com. Retrieved 8 January 2022.
  2. 2.0 2.1 2.2 2.3 2.4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 891. ISBN 978-0857114105.
  3. 3.0 3.1 "Simulect". Retrieved 8 January 2022.
  4. "Simulect Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 8 January 2022.
  5. MedlinePlus. Last Revised - June 15, 2012 Basiliximab Injection
  6. Katsambas AD, Lotti TM (2003). European handbook of dermatological treatments (2nd ed.). p. 291. ISBN 3-540-00878-0.
  7. 7.0 7.1 Hardinger KL, Brennan DC, Klein CL (July 2013). "Selection of induction therapy in kidney transplantation". Transplant International. 26 (7): 662–72. doi:10.1111/tri.12043. PMID 23279211. S2CID 3296555.
  8. 8.0 8.1 Basiliximab label
  9. Waldmann TA (March 2003). "Immunotherapy: past, present and future". Nature Medicine. 9 (3): 269–77. doi:10.1038/nm0303-269. PMID 12612576. S2CID 9745527.

External links

Identifiers: