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Combination of
Lamivudinenucleoside reverse transcriptase inhibitor
Nevirapinenon-nucleoside reverse transcriptase inhibitor
Zidovudinenucleoside reverse transcriptase inhibitor
Trade namesDuovir-N, Zidovex-LN, others[1]
Clinical data
Defined daily dosenot established[2]

Lamivudine/nevirapine/zidovudine (3TC/NVP/AZT) is a fixed-dose combination medication used to treat HIV/AIDS.[3] It contains lamivudine, nevirapine, and zidovudine.[3] It is either used by itself or along with other antiretrovirals.[3] It is a recommended treatment in those who are pregnant.[3] It is taken by mouth twice a day.[3]

The medication is generally well tolerated.[1] Side effects are those of the underlying medications.[3] This includes rash, pancreatitis, low white blood cell levels, and muscle pain.[1] Use is not recommended in those with significant liver problems.[1] Use in pregnancy and breastfeeding appear to be safe.[1] The combination tablet is typically not appropriate for children.[3]

It was on the World Health Organization's List of Essential Medicines; however, was removed.[4][5] The wholesale cost in the developing world is about 8 to 19 USD a month as of 2014.[6] The combination is not commercially available in the United States as of 2018.[7]


The defined daily dose is not established[2]

See also


  1. 1.0 1.1 1.2 1.3 1.4 "Nevirapine, zidovudine and lamivudine" (PDF). aidsmap. Archived from the original (PDF) on 20 December 2016. Retrieved 18 December 2016.
  2. 2.0 2.1 "WHOCC - ATC/DDD Index". Archived from the original on 9 August 2020. Retrieved 18 September 2020.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 157, 161. hdl:10665/44053. ISBN 9789241547659.
  4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. "Additions and deletions of medicines on the WHO model lists of essential medicines: 1977-2017". WHO. Archived from the original on 8 July 2023. Retrieved 15 September 2023.
  6. "Lamivudine + Zidovudine + Nevirapine". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
  7. "Drugs@FDA: FDA Approved Drug Products". Archived from the original on 28 June 2017. Retrieved 6 January 2018.

External links