Lamivudine/nevirapine/stavudine

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Lamivudine/nevirapine/stavudine
Combination of
Lamivudinenucleoside reverse transcriptase inhibitor
Nevirapinenon-nucleoside reverse transcriptase inhibitor
Stavudinenucleoside reverse transcriptase inhibitor
Names
Trade namesTriomune, others
Clinical data
Defined daily dosenot established[1]

Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a medication used to treat HIV/AIDS.[2] It is a fixed dose combination of lamivudine, nevirapine, and stavudine.[2] It is either used by itself or along with other antiretrovirals.[2] It is taken by mouth twice a day.[2]

The medication is generally well tolerated.[3] Side effects are those of the underlying medications.[2] This may include rash, numbness, pancreatitis, and high blood lactate levels.[3] Use is not recommended in those with significant liver problems.[3] It is unclear if use in pregnancy is safe for the baby and recommendations include starting in the second trimester if possible.[3]

It is on the World Health Organization's List of Essential Medicines.[4] The wholesale cost in the developing world is about 9.56 USD per month.[5] As of 2015 it is not commercially available in the United States.[6]

Medical uses

It is a common first line treatment in the developing world.[7]

Dosage

The defined daily dose is not established.[1]

References

  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 18 September 2020. CS1 maint: discouraged parameter (link)
  2. 2.0 2.1 2.2 2.3 2.4 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 160. hdl:10665/44053. ISBN 9789241547659.
  3. 3.0 3.1 3.2 3.3 "Nevirapine/stavudine/lamivudine" (PDF). aidsmap. Archived from the original (PDF) on 20 December 2016. Retrieved 18 December 2016. CS1 maint: discouraged parameter (link)
  4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. "Lamivudine + Stavudine + Nevirapine". International Drug Price Indicator Guide. Retrieved 8 December 2016. CS1 maint: discouraged parameter (link)
  6. Kasper, Dennis L.; Fauci, Anthony S.; Hauser, Stephen; Longo, Dan; Jameson, J. Larry; Loscalzo, Joseph (2015). Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2). McGraw Hill Professional. p. 1277. ISBN 9780071802161. Archived from the original on 2016-12-20. CS1 maint: discouraged parameter (link)
  7. Siegfried, NL; Van Deventer, PJ; Mahomed, FA; Rutherford, GW (19 April 2006). "Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults". The Cochrane Database of Systematic Reviews (2): CD004535. doi:10.1002/14651858.CD004535.pub2. PMID 16625606.

External links

Identifiers: