|Side effects||Headache, diarrhea, nausea, difficulty sleeping|
Dolutegravir/lamivudine, sold under the brand name Dovato, is a combination medication used to treat HIV/AIDS. It may be a first line treatment option. It may, also be the only medication a person requires. It is taken by mouth.
Common side effects are headache, diarrhea, nausea, and difficulty sleeping. Other side effects may include allergic reactions, rash, and liver problems. While there is no evidence of harm in pregnancy, such use has not been well studied. It contains dolutegravir, an integrase inhibitor, and lamivudine, a reverse-transcriptase inhibitor. Dolutegravir stops the activity of integrase, while lamivudine stops the activity of nucleoside reverse transcriptase.
The combination was approved for medical use in the United States and Europe in 2019. It is a generic medication. In the United Kingdom a month of treatment costs the NHS about £660 as of 2021. In the United States this amount costs about 2,500 USD.
In the EU dolutegravir/lamivudine is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine.
Two main studies, involving 1,441 subjects, have shown that the combination of dolutegravir and lamivudine is as effective at lowering the amount of HIV in the blood as a triple combination therapy (dolutegravir plus tenofovir plus emtricitabine).
In these studies, 91% of subjects with HIV-1 who took the dolutegravir/lamivudine combination no longer had detectable levels of HIV (below 50 copies per ml) after 48 weeks compared with 93% of those who were taking the triple combination. In both studies there were no cases of resistance to treatment after 48 weeks.
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