IL36B

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IL36B
Identifiers
AliasesIL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta, interleukin 36 beta
External IDsOMIM: 605508 MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014438
NM_173178

NM_027163

RefSeq (protein)

NP_055253
NP_775270

NP_081439

Location (UCSC)Chr 2: 113.02 – 113.05 MbChr 2: 24.04 – 24.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.[5][6][7][8]

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136696 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026985 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
  6. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
  7. ^ Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes". Arthritis Research & Therapy. 8 (3): R80. doi:10.1186/ar1946. PMC 1526623. PMID 16646978.
  8. ^ a b "Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)".

Further reading