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Available structures
PDBOrtholog search: PDBe RCSB
AliasesCCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
External IDsOMIM: 602737 MGI: 1349183 HomoloGene: 2247 GeneCards: CCL21
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 9: 34.71 – 34.71 MbChr 4: 42.77 – 42.77 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).[5][6][7] The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.[8]

In human lymph nodes, the fibroblastic reticular cells (FRCs) express CCL21 as a chemoattractant to guide naive, CCR7 expressing T cells to the T cell zone.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137077 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094686 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hedrick JA, Zlotnik A (August 1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". Journal of Immunology. 159 (4): 1589–93. PMID 9257816.
  6. ^ Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (September 1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". Journal of Immunology. 159 (6): 2554–8. PMID 9300671.
  7. ^ Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (August 1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". The Journal of Biological Chemistry. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
  8. ^ Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (March 1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". The Journal of Biological Chemistry. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024.
  9. ^ Mueller SN, Germain RN (September 2009). "Stromal cell contributions to the homeostasis and functionality of the immune system". Nature Reviews. Immunology. 9 (9): 618–29. doi:10.1038/nri2588. PMC 2785037. PMID 19644499.

External links

Further reading