IL22RA1

IL22RA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DGC, 3DLQ
Identifiers
Aliases	IL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1
External IDs	OMIM: 605457 MGI: 2663588 HomoloGene: 10943 GeneCards: IL22RA1
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.11 Start 24,119,771 bp End 24,143,140 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D3|4 67.99 cM Start 135,455,483 bp End 135,479,451 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas jejunal mucosa skin of abdomen pancreatic ductal cell duodenum rectum vulva oral cavity islet of Langerhans epithelium of esophagus Top expressed in jejunum ileum colon duodenum lip zone of skin yolk sac esophagus liver kidney More reference expression data BioGPS n/a
Gene ontology Molecular function interferon receptor activity protein binding interleukin-20 binding cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process defense response to Gram-negative bacterium biological process cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58985 230828 Ensembl ENSG00000142677 ENSMUSG00000037157 UniProt Q8N6P7 Q80XZ4 RefSeq (mRNA) NM_021258 NM_178257 RefSeq (protein) NP_067081 NP_839988 Location (UCSC) Chr 1: 24.12 – 24.14 Mb Chr 4: 135.46 – 135.48 Mb PubMed search
Wikidata
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Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.

Function

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

Further reading

• Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I (September 2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–92. doi:10.1016/j.febslet.2008.07.046. PMID 18675809. S2CID 20952148.
• Jones BC, Logsdon NJ, Walter MR (September 2008). "Structure of IL-22 bound to its high-affinity IL-22R1 chain". Structure. 16 (9): 1333–44. doi:10.1016/j.str.2008.06.005. PMC 2637415. PMID 18599299.
• de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I (April 2009). "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters. 583 (7): 1072–7. doi:10.1016/j.febslet.2009.03.006. PMID 19285080.
• Dumoutier L, de Meester C, Tavernier J, Renauld JC (September 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain". The Journal of Biological Chemistry. 284 (39): 26377–84. doi:10.1074/jbc.M109.007955. PMC 2785325. PMID 19632985.
• Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA (October 2008). "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–83. doi:10.1016/j.jmb.2008.07.046. PMID 18675824.
• Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C (August 2010). "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation". Journal of Molecular Cell Biology. 2 (4): 223–30. doi:10.1093/jmcb/mjq017. PMC 2948820. PMID 20671117.
• Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S (January 2001). "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes". The Journal of Biological Chemistry. 276 (4): 2725–32. doi:10.1074/jbc.M007837200. PMID 11035029.
• Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q (December 2012). "Th17-associated cytokines promote human airway smooth muscle cell proliferation". FASEB Journal. 26 (12): 5152–60. doi:10.1096/fj.12-208033. PMID 22898922. S2CID 205369384.
• Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y (March 2008). "Interleukin 22 receptor 1 expression in pancreas islets". Pancreas. 36 (2): 197–9. doi:10.1097/MPA.0b013e3181594258. PMID 18376313. S2CID 26713011.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.