CXCL6

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CXCL6
Identifiers
AliasesCXCL6, CKA-3, GCP-2, GCP2, SCYB6, C-X-C motif chemokine ligand 6
External IDsOMIM: 138965 MGI: 1096868 HomoloGene: 88671 GeneCards: CXCL6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002993

NM_009141

RefSeq (protein)

NP_002984

NP_033167

Location (UCSC)Chr 4: 73.84 – 73.85 MbChr 5: 90.91 – 90.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Identifiers
SymbolCXCL6
Alt. symbolsSCYB6, GCP-2, CKA-3
NCBI gene6372
HGNC10643
OMIM138965
RefSeqNM_002993
UniProtP80162
Other data
LocusChr. 4 q21

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.[5][6] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.[6] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.
  6. ^ a b Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.
  7. ^ Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.
  8. ^ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.