Antimigraine drug

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Antimigraine drug
Drug class
Zolmitriptan Structure V.1.svg
Zolmitriptan, a common antimigraine medication
Class identifiers
UseMigraine therapy and prevention
ATC codeN02C
Clinical data
Drugs.comDrug Classes
In Wikidata

Antimigraine drugs are medications intended to reduce the effects or intensity of migraine headache. They include drugs for the treatment of acute migraine symptoms as well as drugs for the prevention of migraine attacks.[1]


Treatment of acute symptoms

Migraine can often be treated with unspecific analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) or paracetamol, with or without metoclopramide. Examples of specific antimigraine drugs include triptans[2] such as zolmitriptan[3] and ergot alkaloids such as methysergide.


First-line drugs for the prevention of migraine attacks include the beta blockers propranolol, metoprolol and bisoprolol, the antiepileptics valproic acid and topiramate, as well as flunarizine. Less well evidenced is the use of amitriptyline, venlafaxine, Petasites albus extract, riboflavin (vitamin B2), magnesium, coenzyme Q10, gabapentin, acetylsalicylic acid, and naproxen.[1]


  1. ^ a b Mutschler, Ernst (2013). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 232–5. ISBN 978-3-8047-2898-1.
  2. ^ > Serotonin (5-HT): receptors, agonists and antagonists Archived 2009-09-15 at the Wayback Machine By Flavio Guzmán, M.D. on 9/08/09
  3. ^ Morikawa T, Matsuzawa Y, Makita K, Katayama Y (2006). "Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons". Molecular Pain. 2 (1): 10. doi:10.1186/1744-8069-2-10. PMC 1434723. PMID 16549032.