Villonodular synovitis

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Villonodular synovitis
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a,b)Bilateral pigmented villonodular synovitis of the knee.
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Villonodular synovitis is a type of synovial swelling.

Types include:

Though they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin.[1] They are sometimes discussed together.[2][3][4]


  1. O'Connell JX, Fanburg JC, Rosenberg AE (July 1995). "Giant cell tumor of tendon sheath and pigmented villonodular synovitis: immunophenotype suggests a synovial cell origin". Human Pathology. 26 (7): 771–5. doi:10.1016/0046-8177(95)90226-0. PMID 7628850.
  2. Mackie GC (November 2003). "Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases". Clinical Nuclear Medicine. 28 (11): 881–5. doi:10.1097/01.rlu.0000093083.77866.5c. PMID 14578700.
  3. Maheshwari AV, Muro-Cacho CA, Pitcher JD (October 2007). "Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature". Knee. 14 (5): 402–7. doi:10.1016/j.knee.2007.06.004. PMID 17669658.
  4. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA (2008). "Pigmented villonodular synovitis: radiologic-pathologic correlation". Radiographics. 28 (5): 1493–518. doi:10.1148/rg.285085134. PMID 18794322.