Plica syndrome

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Plica syndrome
Other names: Synovial plica syndrome

Plica syndrome is a condition that occurs when a plica (a vestigial extension of the protective synovial capsule of usually the knee) becomes irritated, enlarged, or inflamed.[1]

Signs and symptoms

The clinical presentation of Plica syndrome are pain, crepitus or effusion[2]


This inflammation is typically caused by the plica being caught on the femur, or pinched between the femur and the patella. The most common location of plica tissue is along the medial (inside) side of the knee. The plica can tether the patella to the femur, be located between the femur and patella, or be located along the femoral condyle. If the plica tethers the patella to the femoral condyle, the symptoms may cause it to be mistaken for chondromalacia.

The plica themselves are remnants of the fetal stage of development where the knee is divided into three compartments. The plica normally diminish in size during the second trimester of fetal development, as the three compartments develop into the synovial capsule. In adults, they normally exist as sleeves of tissue called synovial folds. The plica are usually harmless and unobtrusive; plica syndrome only occurs when the synovial capsule becomes irritated, which thickens the plica themselves (making them prone to irritation/inflammation, or being caught on the femur).


a)Diagnosis of mediopatellar plica on arthroscopy demonstrating plica ischemia with thickening, stiffening and elasticity loss b)medial patellar plica

If the plica tethers the patella to the femoral condyle, the symptoms may cause it to be mistaken for chondromalacia patellae. Diagnosis is often complicated by the thin structures of plicae, fenestrated septum or unfenestrated septum all being too fine to resolve well even in MRI.


Plica syndrome treatment focuses on decreasing inflammation of the synovial capsule. A nonsteroidal anti-inflammatory drug (NSAID) is often used in conjunction with therapeutic exercise and modalities. Iontophoresis and phonophoresis have been utilized successfully against inflammation of the plica and synovial capsule. Failing these, surgical removal of the plica of the affected knee may be necessary.

See also


  1. Casadei, Kyle; Kiel, John (2020). "Plica Syndrome". StatPearls. StatPearls Publishing. PMID 30570983. Archived from the original on 7 February 2023. Retrieved 9 January 2021.
  2. Ravikanth, Reddy; Pilar, Anoop; Majumdar, Pooja (2020). "Magnetic resonance assessment of medial plica syndrome of knee from child to adult with arthroscopic correlation: A single center experience and literature review". Tzu Chi Medical Journal. 32 (4): 351. doi:10.4103/tcmj.tcmj_150_19. Archived from the original on 7 February 2023. Retrieved 6 February 2023.

External links

External resources