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Other namesFluticasone propionate, fluticasone furoate
  • S-fluoromethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
Clinical data
Drug classGlucocorticoid[1]
Main usesAsthma, COPD, allergic rhinitis[1][2]
Side effectsInhaled: Upper respiratory tract infections, throat irritation, candidiasis, cough, headache[1]
Nose: Burning, nosebleeds, nausea, sore throat[2]
Routes of
Intranasal, inhaled, topical
External links
AHFS/Drugs.comInhaled: Monograph
Nose: Monograph
US NLMFluticasone
Legal status
Bioavailability0.51% (Intranasal)
Protein binding91.0%
Liver (CYP3A4-mediated)
Elimination half-life10 hours
Chemical and physical data
Molar mass444.51 g·mol−1
3D model (JSmol)
  • O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
  • InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 checkY
 ☒NcheckY (what is this?)  (verify)

Fluticasone is a steroid which is used to treat asthma, COPD, and allergic rhinitis.[1][2] For asthma and COPD it is used for long term management.[1] It is used by breathing it into the lungs or as a nasal spray.[1][2]

Common side effects of the inhaled form include upper respiratory tract infections, throat irritation, candidiasis, cough, and headache.[1] Commons side effects of the nasal spray include a brief period of burning, nosebleeds, nausea, and sore throat.[2] It comes in two main forms fluticasone propionate and fluticasone furoate.[3]

Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[4] In the United Kingdom 60 doses of 250 micrograms for breathing in costs the NHS about £25.[3] In 2018, it was the sixteenth most commonly prescribed medication in the United States, with more than 34 million prescriptions.[5][6] It is also available in combination as fluticasone/formoterol and fluticasone/salmeterol, among others.[3]

Medical uses



There are two manufactured forms.[7][8][9][10][11] They are both esters, fluticasone furoate and fluticasone propionate.[9][8][10][12]

Chemically it is known as 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Fluticasone (Systemic, Oral Inhalation) Monograph for Professionals". Drugs.com. Retrieved 14 December 2021.
  2. 2.0 2.1 2.2 2.3 2.4 "Fluticasone (EENT) Monograph for Professionals". Drugs.com. Retrieved 14 December 2021.
  3. 3.0 3.1 3.2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 278. ISBN 978-0857114105.
  4. Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495.
  5. "The Top 300 of 2021". ClinCalc. Retrieved 18 February 2021.
  6. "Fluticasone - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021.
  7. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 574–. ISBN 978-1-4757-2085-3.
  8. 8.0 8.1 Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1.
  9. 9.0 9.1 Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 124–. ISBN 978-94-011-4439-1.
  10. 10.0 10.1 https://www.drugs.com/international/fluticasone.html
  11. Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 600. ISBN 978-1451153590.
  12. Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. p. 748. ISBN 978-1111310653.

External links

External sites: