|Other names||N, N-diethyl-4-methyl-1-piperazine carboxamide|
|Main uses||Lymphatic filariasis|
|Defined daily dose||400 mg|
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|Chemical and physical data|
|Molar mass||199.298 g·mol−1|
|3D model (JSmol)|
|Melting point||47 to 49 °C (117 to 120 °F)|
Diethylcarbamazine (DEC) is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. It may also be used for prevention of loiasis in those at high risk. While it has been used for onchocerciasis (river blindness), ivermectin is preferred. It is taken by mouth.
Common side effects include itching, facial swelling, headaches, and feeling tired. Other side effects include vision loss and dizziness. It is a recommended treatment in pregnancy and appears to be safe for the baby. The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible. It is made from 4-methyl-piperazine.
Diethylcarbamazine was discovered in 1947. It is on the World Health Organization's List of Essential Medicines. The wholesale cost in the developing world is around one US penny per dose. It is not commercially available in the United States but can be acquired from the Center for Disease Control.
DEC is indicated for treatment of individual patients with certain filarial diseases, including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia; and loiasis.
In cases of onchocerciasis, another common filarial parasite, the drug is effective.
DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis.
Now, the WHO recommends prescribing DEC to people who are infected with microfilariae of filarial parasites and also to control transmission of infection in filariasis-endemic areas.
The defined daily dose is 400 mg (by mouth). The dose in those over the age of 10 is 1 mg/kg on the first day which is than increased to 2 mg/kg three times a day over the next three days. In those under 10 years old the dose is half of this. Treatment duration is between six and 12 days.
Contraindications are previous history of heart problems, gastrointestinal problems, and allergies.[medical citation needed]
Pregnancy and breastfeeding
Society and culture
- Banocide Forte
DEC is also used to prevent heartworm in dogs.
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-  WHO: Unfulfilled potential: using diethylcarbamazine-fortified salt to eliminate lymphatic filariasis