KIF3A

KIF3A
Identifiers
Aliases	KIF3A, FLA10, KLP-20, kinesin family member 3A
External IDs	OMIM: 604683 MGI: 107689 HomoloGene: 38266 GeneCards: KIF3A
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.1 Start 132,692,628 bp End 132,737,638 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 31.97 cM Start 53,458,206 bp End 53,492,794 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus secondary oocyte pons entorhinal cortex postcentral gyrus superior vestibular nucleus sural nerve superior frontal gyrus Top expressed in ventromedial nucleus mammillary body dorsomedial hypothalamic nucleus lens paraventricular nucleus of hypothalamus supraoptic nucleus medial vestibular nucleus spermatid neural tube saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity spectrin binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding ATPase activity protein phosphatase binding Cellular component cytoplasm cytosol centrosome cell projection microtubule cytoskeleton kinesin II complex ciliary tip spindle microtubule extracellular exosome cytoskeleton microtubule centriole cilium kinesin complex axon cytoplasm Biological process plus-end-directed vesicle transport along microtubule antigen processing and presentation of exogenous peptide antigen via MHC class II organelle organization microtubule-based movement cell projection organization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum neurogenesis centriole-centriole cohesion microtubule anchoring at centrosome intraciliary transport involved in cilium assembly cilium assembly axon guidance anterograde axonal transport protein transport protein localization to cell junction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11127 16568 Ensembl ENSG00000131437 ENSMUSG00000018395 UniProt Q9Y496 P28741 RefSeq (mRNA) NM_001300791 NM_001300792 NM_007054 NM_001290805 NM_001290806 NM_008443 RefSeq (protein) NP_001287720 NP_001287721 NP_008985 NP_001277734 NP_001277735 NP_032469 Location (UCSC) Chr 5: 132.69 – 132.74 Mb Chr 11: 53.46 – 53.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.

Function

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

Interactions

KIF3A has been shown to interact with MAP3K10.

Further reading

• Aizawa H, Sekine Y, Takemura R, et al. (1992). "Kinesin family in murine central nervous system". J. Cell Biol. 119 (5): 1287–96. doi:10.1083/jcb.119.5.1287. PMC 2289715. PMID 1447303.
• Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport". J. Cell Biol. 130 (6): 1387–99. doi:10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
• Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi:10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
• Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.
• Hasegawa T, Yagi A, Isobe K (2000). "Interaction between GADD34 and kinesin superfamily, KIF3A". Biochem. Biophys. Res. Commun. 267 (2): 593–6. doi:10.1006/bbrc.1999.1991. PMID 10631107.
• Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.
• Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi:10.1242/jcs.00058. PMID 12235292.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes". Traffic. 6 (12): 1114–24. doi:10.1111/j.1600-0854.2005.00347.x. PMID 16262723. S2CID 25560378.
• Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". J. Biol. Chem. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
• Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
• Pantelidou M, Zographos SE, Lederer CW, et al. (2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS". Neurobiol. Dis. 26 (3): 577–89. doi:10.1016/j.nbd.2007.02.005. PMID 17418584. S2CID 2838469.