Unconventional myosin-Ia

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MYO1A
Identifiers
AliasesMYO1A, BBMI, DFNA48, MIHC, MYHL, myosin IA
External IDsOMIM: 601478 MGI: 107732 HomoloGene: 21113 GeneCards: MYO1A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256041
NM_005379

NM_001081219

RefSeq (protein)

NP_001242970
NP_005370

NP_001074688

Location (UCSC)Chr 12: 57.03 – 57.05 MbChr 10: 127.54 – 127.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unconventional myosin-Ia is a protein that in humans is encoded by the MYO1A gene.[5][6][7]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-Ia protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to the brush border. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the unconventional myosin-Ia protein binds to the actin core bundle, which turns over on a much slower timescale.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166866 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025401 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
  6. ^ Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell RE, Melchionda S, Zelante L, Avraham KB, Gasparini P (May 2003). "Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss". Am J Hum Genet. 72 (6): 1571–7. doi:10.1086/375654. PMC 1180318. PMID 12736868.
  7. ^ "MYO1A - Unconventional myosin-Ia - Homo sapiens (Human) - MYO1A gene & protein". www.uniprot.org. Retrieved 7 April 2022.
  8. ^ Tyska MJ, Mooseker MS (April 2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. Bibcode:2002BpJ....82.1869T. doi:10.1016/S0006-3495(02)75537-9. PMC 1301984. PMID 11916846. Archived from the original on 2007-12-27.

Further reading