Troponin C, skeletal muscle

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TNNC2
Identifiers
AliasesTNNC2, troponin C2, fast skeletal type, CFAP85, FAP85
External IDsOMIM: 191039 MGI: 98780 HomoloGene: 55727 GeneCards: TNNC2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003279

NM_009394

RefSeq (protein)

NP_003270

NP_033420

Location (UCSC)Chr 20: 45.82 – 45.83 MbChr 2: 164.62 – 164.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[5][6]

Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. The TnI subunit inhibits actomyosin ATPase, the TnT subunit binds tropomyosin and TnC, while the TnC subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin thin filaments. The protein encoded by the TNNC2 gene is the TnC subunit.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101470 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017300 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem. 265 (21): 12520–8. doi:10.1016/S0021-9258(19)38376-0. PMID 2373703.
  6. ^ a b "Entrez Gene: TNNC2 troponin C type 2 (fast)".

Further reading