KIF2A
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Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.[5][6] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.[7]
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.
- ^ a b "Entrez Gene: KIF2A kinesin heavy chain member 2A".
- ^ Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46): e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.
Further reading
- Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA (August 2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells". Molecular Biology of the Cell. 18 (8): 2970–2979. doi:10.1091/mbc.E07-02-0110. PMC 1949365. PMID 17538014.
- Schepis A, Stauber T, Krijnse Locker J (August 2007). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle". Cellular Microbiology. 9 (8): 1960–1973. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562. S2CID 23205204.
- Li C, Zheng Y, Qin W, Tao R, Pan Y, Xu Y, et al. (October 2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia". Neuroscience Letters. 407 (2): 151–155. doi:10.1016/j.neulet.2006.08.025. PMID 16959419. S2CID 32742823.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Ganem NJ, Upton K, Compton DA (October 2005). "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology. 15 (20): 1827–1832. Bibcode:2005CBio...15.1827G. doi:10.1016/j.cub.2005.08.065. PMID 16243029. S2CID 8541946.
- Ganem NJ, Compton DA (August 2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology. 166 (4): 473–478. doi:10.1083/jcb.200404012. PMC 2172212. PMID 15302853.
- Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. (December 2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–2144. Bibcode:2003Sci...302.2141J. CiteSeerX 10.1.1.1017.9438. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.
External links
- Overview of all the structural information available in the PDB for UniProt: O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB.
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