DYNLL2

DYNLL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	58,095,542 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	87,878,359 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; sperm; ; pons; ; superior vestibular nucleus; ; ventral tegmental area; ; external globus pallidus; ; parietal lobe; ; postcentral gyrus; ; subthalamic nucleus; ; superior frontal gyrus;
	Top expressed in
	motor neuron; ; mammillary body; ; lateral hypothalamus; ; lateral geniculate nucleus; ; seminiferous tubule; ; ventromedial nucleus; ; medial vestibular nucleus; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal motor activity; protein binding; plus-end-directed microtubule motor activity; dynein intermediate chain binding; dynein light intermediate chain binding; cytoskeletal protein binding; protein homodimerization activity; protein heterodimerization activity; scaffold protein binding;
Cellular component	cytoplasm; cytosol; nucleus; membrane; ciliary tip; centrosome; microtubule; plasma membrane; microtubule associated complex; dynein complex; cytoskeleton; mitochondrion; cilium; myosin V complex; cytoplasmic dynein complex; myosin complex; postsynaptic density; postsynapse; glutamatergic synapse;
Biological process	microtubule-based process; antigen processing and presentation of exogenous peptide antigen via MHC class II; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; macroautophagy; intraciliary transport involved in cilium assembly; transport along microtubule; cilium assembly; sister chromatid cohesion; transport;
	Sources:Amigo / QuickGO
Orthologs
	140735
	68097
	ENSG00000264364
	ENSMUSG00000020483
	Q96FJ2
	Q9D0M5
	NM_080677
	NM_001168471; NM_001168472; NM_026556
	NP_542408
	NP_001161943; NP_001161944; NP_080832
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^[5]^[6]

Interactions

DYNLL2 has been shown to interact with DLG4,^[7] C12orf40,^[8] DLGAP1,^[7] MYO5A^[7]^[9] and BMF.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000264364 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
^ ^a ^b ^c Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12). UNITED STATES: 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. ISSN 0270-6474. PMC 6772433. PMID 10844022.
^ Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
^ ^a ^b Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536). United States: 1829–32. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. S2CID 5638023.
^ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3). England: 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.