Centrin 1

CETN1
Identifiers
Aliases	CETN1, CEN1, CETN, centrin 1
External IDs	OMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.32 Start 580,380 bp End 582,114 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 9,615,524 bp End 9,619,478 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm human musculoskeletal system muscular system muscle muscle gland human thorax male reproductive gland integument prostate Top expressed in spermatid spermatocyte seminiferous tubule motor neuron submandibular gland spinal ganglia carotid body trachea triceps brachii muscle blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding calcium ion binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding protein binding metal ion binding Cellular component cytoplasm microtubule organizing center centrosome spindle pole cytoskeleton photoreceptor connecting cilium centriole nucleus Biological process cell cycle cellular response to heat cell division mitotic cytokinesis centriole replication regulation of centrosome duplication calcium-mediated signaling regulation of cytokinesis microtubule cytoskeleton organization nucleotide-excision repair mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1068 26369 Ensembl ENSG00000177143 ENSMUSG00000050996 UniProt Q12798 P41209 RefSeq (mRNA) NM_004066 NM_007593 RefSeq (protein) NP_004057 NP_031619 Location (UCSC) Chr 18: 0.58 – 0.58 Mb Chr 18: 9.62 – 9.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.

External links

• Human CETN1 genome location and CETN1 gene details page in the UCSC Genome Browser.

Further reading

• Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
• Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. hdl:10536/DRO/DU:30131061. PMID 16246726.
• Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678. S2CID 36574274.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
• Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113. ( Pt 8) (8): 1355–64. doi:10.1242/jcs.113.8.1355. PMID 10725219.