KRT85

KRT85
Identifiers
Aliases	KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85
External IDs	OMIM: 602767 HomoloGene: 37603 GeneCards: KRT85
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 52,360,006 bp End 52,367,481 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm hair follicle nipple right lung skin of abdomen body of tongue human penis placenta myometrium kidney n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament keratin filament extracellular space cytosol Biological process epidermis development keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3891 n/a Ensembl ENSG00000135443 n/a UniProt P78386 n/a RefSeq (mRNA) NM_002283 NM_001300810 n/a RefSeq (protein) NP_001287739 NP_002274 n/a Location (UCSC) Chr 12: 52.36 – 52.37 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Naeem M, Wajid M, Lee K, et al. (2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type". J. Med. Genet. 43 (3): 274–9. doi:10.1136/jmg.2005.033381. PMC 2563238. PMID 16525032.
• Tang K, Finley RL, Nie D, Honn KV; Finley (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry. 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Rogers MA, Winter H, Langbein L, et al. (1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J. Invest. Dermatol. 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.