Myosin-XVIIIb is a protein that in humans is encoded by the MYO18Bgene.[5][6][7]
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[7]
^Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID12547197.
Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID12741677. S2CID22741542.
Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID16499872.
Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. doi:10.3727/000000006783981062. PMID17294804.
