MYO18A

MYO18A
Identifiers
Aliases	MYO18A, MYSPDZ, SPR210, myosin XVIIIA, MAJN, SP-R210
External IDs	OMIM: 610067 MGI: 2667185 HomoloGene: 7977 GeneCards: MYO18A
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 29,071,122 bp End 29,180,398 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 77,763,246 bp End 77,865,980 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue sural nerve left ventricle corpus callosum right lobe of liver skin of abdomen bone marrow cells putamen nucleus accumbens Top expressed in esophagus lip triceps brachii muscle ankle right ventricle temporal muscle skeletal muscle tissue intestinal villus internal carotid artery knee joint More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding ADP binding actin filament binding ATPase activity protein binding ATP binding RNA binding Cellular component cytoplasm membrane trans-Golgi network actomyosin cytoskeleton myosin complex endoplasmic reticulum-Golgi intermediate compartment Golgi membrane Golgi apparatus cell surface Biological process Golgi organization Golgi vesicle budding actomyosin structure organization DNA metabolic process asymmetric Golgi ribbon formation negative regulation of apoptotic process positive regulation of protein secretion cell migration Golgi ribbon formation regulation of macrophage activation positive regulation of opsonization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 399687 360013 Ensembl ENSG00000196535 ENSMUSG00000000631 UniProt Q92614 Q9JMH9 RefSeq (mRNA) NM_001346765 NM_001346766 NM_001346767 NM_001346768 NM_078471 NM_203318 NM_001291212 NM_001291213 NM_001291214 NM_001291215 NM_011586 RefSeq (protein) NP_001333694 NP_001333695 NP_001333696 NP_001333697 NP_510880 NP_976063 NP_001278141 NP_001278142 NP_001278143 NP_001278144 NP_035716 Location (UCSC) Chr 17: 29.07 – 29.18 Mb Chr 11: 77.76 – 77.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.

Further reading

• Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996). "Purification of a cell-surface receptor for surfactant protein A." J. Biol. Chem. 271 (27): 16375–83. doi:10.1074/jbc.271.27.16375. PMID 8663107.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Chang NS, Mattison J, Cao H, et al. (1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem. Biophys. Res. Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
• Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
• Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site". Biochemistry. 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Yang CH, Szeliga J, Jordan J, et al. (2005). "Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A". J. Biol. Chem. 280 (41): 34447–57. doi:10.1074/jbc.M505229200. PMC 1762002. PMID 16087679.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.