Protein-coding gene in the species Homo sapiens
Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene .[5] [6] [7]
In melanocytic cells DYNC1I1 gene expression may be regulated by MITF .[8]
Interactions DYNC1I1 has been shown to interact with DYNLL1 .[9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000158560 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029757 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics . 55 (3): 257–67. doi :10.1006/geno.1998.5665 . PMID 10049579 . ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature" . J Cell Biol . 171 (3): 411–3. doi :10.1083/jcb.200508078 . PMC 2171247 PMID 16260502 . ^ "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1" .^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 . S2CID 24698373 . ^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50). United States: 14906–15. doi :10.1021/bi026417u . ISSN 0006-2960 . PMID 12475239 .
Further reading
King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein" . J. Biol. Chem . 271 (50): 32281–7. doi :10.1074/jbc.271.50.32281 PMID 8943288 . Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif" . J. Biol. Chem . 276 (17): 14059–66. doi :10.1074/jbc.M010320200 PMID 11148209 . Horikawa I, Parker ES, Solomon GG, Barrett JC (2001). "Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells" . J. Cell. Biochem . 82 (3): 415–21. doi :10.1002/jcb.1169 . PMID 11500918 . S2CID 10899690 . Karki S, Ligon LA, DeSantis J, et al. (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact" . Mol. Biol. Cell . 13 (5): 1722–34. doi :10.1091/mbc.02-02-0011 . PMC 111139 PMID 12006665 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ligon LA, Tokito M, Finklestein JM, et al. (2004). "A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity" . J. Biol. Chem . 279 (18): 19201–8. doi :10.1074/jbc.M313472200 PMID 14985359 . Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs" . Nucleic Acids Res . 32 (8): 2411–20. doi :10.1093/nar/gkh552 . PMC 419443 PMID 15121898 . Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth" . Dev. Cell . 9 (1): 75–86. doi :10.1016/j.devcel.2005.04.003 . PMC 3857739 PMID 15992542 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
