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Combination of
ValsartanAngiotensin II receptor antagonist
HydrochlorothiazideThiazide diuretic
Trade namesCo-vasotec, Diovan HCT, Co-Diovan, others
Clinical data
Routes of
By mouth
Defined daily dosenot established[1]
External links
AHFS/Drugs.comFDA Professional Drug Information
License data
Legal status

Valsartan/hydrochlorothiazide, sold under the trade name Co-Diovan among others, is an medication used to treat high blood pressure when valsartan is not sufficient.[2] It is a combination of valsartan, an angiotensin receptor blocker with hydrochlorothiazide, a diuretic.[3] It is taken by mouth.[3]

Common side effects include dizziness and headaches.[3] Serious side effects may include allergic reactions, electrolyte abnormalities, and glaucoma.[4] Use in pregnancy is not recommended.[4]

The combination was approved for medical use in the United States in 1998.[3] It is available as a generic medication.[2] A month supply in the United Kingdom costs the NHS about 1.85 as of 2019.[2] In the United States the wholesale cost of this amount is about US$4.40.[5] In 2017, it was the 133rd most commonly prescribed medication in the United States, with more than five million prescriptions.[6][7]


The defined daily dose is not established[1]


  1. 1.0 1.1 "WHOCC - ATC/DDD Index". Retrieved 10 September 2020.
  2. 2.0 2.1 2.2 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
  3. 3.0 3.1 3.2 3.3 "Hydrochlorothiazide and valsartan Uses, Side Effects & Warnings". Retrieved 10 March 2019.
  4. 4.0 4.1 "Valsartan and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Retrieved 10 March 2019.
  5. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  6. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  7. "Hydrochlorothiazide; Valsartan - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

External links