Bazedoxifene/conjugated estrogens

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Bazedoxifene/conjugated estrogens
Combination of
BazedoxifeneSelective estrogen receptor modulator
Conjugated estrogensEstrogen
Trade namesDuavee, Duavive
Clinical data
Main usesSymptoms of menopause, osteoporosis after menopause[1]
Side effectsMuscle spasms, nausea, diarrhea, heart burn, dizziness, pain[1]
  • AU: D[2]
  • US: X (Contraindicated)[2]
Routes of
By mouth
External links
License data
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)

Bazedoxifene/conjugated estrogens, sold under the brand name Duavee and Duavive, is a combination medication used to treat symptoms of menopause and osteoporosis after menopause.[1] It is taken by mouth.[3] It should be used short term.[3]

Common side effects include muscle spasms, nausea, diarrhea, heart burn, dizziness, and pain.[1] Other side effects may include blood clots, stroke, and endometrial cancer.[1] It should not be used in pregnancy.[3] It contains bazedoxifene, a selective estrogen receptor modulator, and conjugated estrogens.[4]

The combination was approved for medical use in the United States in 2013 and Europe in 2014.[1][5] In the United States a month of medication costs about 180 USD as of 2022.[6]

Medical uses


It is taken as one tablet of 0.45 mg conjugated estrogens and 20 mg bazedoxifene a day.[5]

Society and culture


In June 2020, Pfizer recalled two batches of Duavive, its oestrogen replacement product, as a result of concerns raised about faulty packaging.[7]

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Selective Estrogen Receptor Modulators". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 8 January 2022.
  2. 2.0 2.1 "Bazedoxifene / conjugated estrogens (Duavee) Use During Pregnancy". 16 February 2019. Archived from the original on 26 June 2020. Retrieved 23 June 2020.
  3. 3.0 3.1 3.2 "DailyMed - DUAVEE- conjugated estrogens/bazedoxifene tablet, film coated". Archived from the original on 10 May 2021. Retrieved 8 January 2022.
  4. "Bazedoxifene Monograph for Professionals". Archived from the original on 19 April 2021. Retrieved 8 January 2022.
  5. 5.0 5.1 "Duavive EPAR". European Medicines Agency (EMA). Archived from the original on 2020-06-10. Retrieved 2020-06-10.
  6. "Conjugated Estrogens and Bazedoxifene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 16 April 2016. Retrieved 8 January 2022.
  7. "Pfizer recalls 2 batches of Duavive". Zenopa. Archived from the original on 2020-09-27.

External links