Estromustine
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Chemical compound
Not to be confused with Estramustine phosphate or Estramustine.
Clinical data | |
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Other names | EoM; Leo 271 f; Estrone 17β-3-N-bis(2-chloroethyl)carbamate; Estrone–cytostatic complex |
Drug class | Chemotherapeutic agent; Estrogen; Estrogen ester |
Pharmacokinetic data | |
Elimination half-life | 14 hours[1] |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C23H29Cl2NO3 |
Molar mass | 438.39 g·mol−1 |
3D model (JSmol) | |
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Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex,[2] is a major active metabolite of the cytostatic antineoplastic agent and estrogen estramustine phosphate, a medication used in the treatment of prostate cancer.[1][3]
See also
References
- ^ a b Chabner BA, Longo DL (7 December 2011). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 252–. ISBN 978-1-4511-4820-6.
- ^ Yamanaka H, Kitaura K, Imai K, Yuasa H, Nakai K, Matsumura Y, Uehara H, Shida K (1981). "In vivo studies of 3H-estramustine in castrated male rat". Acta Urologica Japonica. 27 (3): 243–50.
- ^ Medical Subject Headings: Supplementary chemical records. The Library. 1993. p. 684.
ARTooltip Androgen receptor |
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GPRC6A |
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Retrieved from "https://mdwiki.org/wiki/Estromustine"
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