RTI-160

From WikiProjectMed
Jump to navigation Jump to search
RTI-160
Identifiers
  • [(2R,3S)-2-(Dimethylcarbamoyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] benzoate
PubChem CID
ChemSpider
Chemical and physical data
FormulaC18H24N2O3
Molar mass316.401 g·mol−1
3D model (JSmol)
  • CN1C2CCC1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)N(C)C
  • InChI=1S/C18H24N2O3/c1-19(2)17(21)16-14-10-9-13(20(14)3)11-15(16)23-18(22)12-7-5-4-6-8-12/h4-8,13-16H,9-11H2,1-3H3/t13?,14?,15-,16+/m0/s1
  • Key:KCJKRDUKFUVPDP-SSHXOBKSSA-N

RTI-160 (benzoylecgonine dimethylamide) is a tropane derivative drug with stimulant effects, having similar potency as a dopamine reuptake inhibitor to cocaine. It is synthesized by an amide condensation reaction between benzoylecgonine and dimethylamine.[1][2]

See also

References

  1. ^ Carroll FI, Kotian P, Dehghani A, Gray JL, Kuzemko MA, Parham KA, et al. (January 1995). "Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. PMID 7830281.
  2. ^ Paula S, Tabet MR, Farr CD, Norman AB, Ball WJ (January 2004). "Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody". Journal of Medicinal Chemistry. 47 (1): 133–142. doi:10.1021/jm030351z. PMID 14695827.
Retrieved from "https://mdwiki.org/wiki/RTI-160"