Pemirolast

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Pemirolast
Names
Trade namesAlamast, Alegysal, others
Other namesPemirolast potassium
  • 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Clinical data
Drug classMast cell stabilizer[1]
Main usesAllergic conjunctivitis[1]
Side effectsHeadache, runny nose[1]
Pregnancy
category
  • US: C (Risk not ruled out)[2]
Routes of
use		By mouth, eye drop
External links
AHFS/Drugs.comMonograph
Legal
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Chemical and physical data
FormulaC10H8N6O
Molar mass228.215 g·mol−1
3D model (JSmol)
  • CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3

Pemirolast, sold under the brand names Alamast among others, is a medication used to treat allergic conjunctivitis.[1] It is used as an eye drop.[1]

Common side effects include headache and runny nose.[1] Safety in pregnancy and breastfeeding is unclear.[2] It is is a mast cell stabilizer.[1]

Pemirolast was approved for medical use in the United States in 1999.[1] As of 2021 it is not commercially available in the United States.[3]

Medical uses

Acute allergic conjunctivitis maybe treated with pemirolast[4]

The combination of levocabastine and pemirolast may be more effective than levocabastine alone.[5]

Dosage

It may be used as 1 to 2 drops up to 4 times per day.[1]

Research

It has also been studied for the treatment of asthma. Pemirolast has appeared as a possible candidate for SARS-CoV-2 (COVID-19) spike protein disruption and interference. Such results were ascertained by molecular dynamics calculations executed on the Summit supercomputer. By simulating compounds with FDA or similar regulatory approval, the authors found 4 interfacial molecules that could potentially disrupt the SARS-CoV-2 interface with ACE-2 receptors, suggesting that such small molecules could mitigate SARS-CoV-2 infection. The 4 candidate interfacial molecules included pemirolast, isoniazid pyruvate, nitrofurantoin, and eriodictyol.[6]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Pemirolast Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 27 October 2021.
  2. ↑ 2.0 2.1 "Pemirolast ophthalmic (Alamast) Use During Pregnancy". Drugs.com. 2 September 2020. Archived from the original on 23 November 2020. Retrieved 13 September 2020.
  3. ↑ "Pemirolast Prices and Pemirolast Coupons - GoodRx". GoodRx. Archived from the original on 13 June 2016. Retrieved 27 October 2021.
  4. ↑ Mishra, Gyan P.; Tamboli, Viral; Jwala, Jwala; Mitra, Ashim K. (January 2011). "Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis". Recent Patents on Inflammation & Allergy Drug Discovery. 5 (1): 26–36. doi:10.2174/187221311794474883. ISSN 1872-213X.
  5. ↑ Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane Database Syst Rev. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608.{{cite journal}}: CS1 maint: uses authors parameter (link)
  6. ↑ Smith, MD, Smith JC (April 2020). "Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface". Preprint: 1–28. Archived from the original on 2020-10-28. Retrieved 2020-12-12.

External links

Identifiers:
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