|Trade names||Boniva, Bonviva, Bondronat, others|
|Other names||Ibandronate sodium|
|By mouth, intravenous|
|US NLM||Ibandronic acid|
|Protein binding||90.9 to 99.5%|
|Elimination half-life||10 to 60 hours|
|Chemical and physical data|
|Molar mass||319.231 g·mol−1|
|3D model (JSmol)|
Ibandronic acid, also known as ibandronate, is a medication used treat of osteoporosis, high calcium due to cancer, and bone metastases from breast cancer. It may be taken by mouth or injection into a vein.
Common side effects include heart burn, low calcium, weakness, headache, and fever. Other side effects may include anaphylaxis, esophagitis, femur fracture, and osteonecrosis of the jaw. It is a bisphosphonate and works by stopping bone breakdown by cells known as osteoclasts.
Ibandronic acid was patented in 1986 by Boehringer Mannheim and approved for medical use in 1996. It is available as a generic medication. In the United Kingdom a 150 mg pill cost the NHS about £4.50 as of 2021. This amount in the United States is about 12 USD.
Ibandronate is indicated for the treatment and prevention of osteoporosis in post-menopausal women. The basis for this approval was a trial of women with post-menopausal osteoporosis. Every participant also received daily oral doses of calcium and 400IUs [international units] of vitamin D. At the study's conclusion, both doses significantly reduced the occurrence risk of new vertebral fractures by 50–52 percent when compared to the effects of the placebo drug.
Ibandronate is efficacious for the prevention of metastasis-related bone fractures in multiple myeloma, breast cancer, and certain other cancers.
For osteoporosis it is take by mouth at a dose of 150 mg per month or by intravenous at a dose of 3 mg every 3 month.
In 2008, the U.S Food and Drug Administration (FDA) issued a communication warning of the possibility of severe and sometimes incapacitating bone, joint or muscle pain. A study conducted by the American Society of Bone and Mineral Research concluded that long-term use of bisphosphonates, including Boniva, may increase the risk of a rare but serious fracture of the femur.  The drug also has been associated with osteonecrosis of the jaw, relatively rare but serious condition.
Society and culture
This medication has a cost in the U.S. of $51 (USD) for 3 tablets (150 mg)
Ibandronic acid is marketed under the trade names Boniva in the USA, Bondronat in Europe, Bonviva in Asia, Bandrone in India, Ibandrix in Ecuador, Adronil in Pakistan, Bondrova in Bangladesh and Bonprove in Egypt.
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