|Trade names||Aredia, Pamimed, among others|
|Other names||Pamidronate disodium pentahydrate, pamidronate disodium (APD)|
|Main uses||High calcium due to cancer, Paget's disease of the bone, bone metastasis that are osteolytic|
|Side effects||Redness and pain at the site of injection, fever, low potassium, low phosphate, bone pain, headache|
|Typical dose||30 mg to 90mg|
|Elimination half-life||28 ± 7 hours|
|Chemical and physical data|
|Molar mass||235.069 g·mol−1|
|3D model (JSmol)|
Pamidronic acid, also known as pamidronate, is a medication used to treat high calcium due to cancer, Paget's disease of the bone, and bone metastasis that are osteolytic. It is given by gradual injection into a vein.
Common side effects include redness and pain at the site of injection, fever, low potassium, low phosphate, bone pain, and headache. Use during pregnancy may harm the baby. It is a bisphosphonate.
Pamidronic acid was patented in 1971 and approved for medical use in 1987. It is available as a generic medication. In the United States it costs less than 70 USD per dose as of 2021. It is sold under the brand name Aredia among others.
It is used to prevent bone loss, and treat osteoporosis. It is also used to strengthen bone in Paget's disease, to prevent bone loss due to steroid use, and in certain cancers with high propensity to bone, such as multiple myeloma. Due to its ability to sequester calcium in bone, it is also used to treat high calcium levels. It is also used as an experimental treatment of the bone disorder osteogenesis imperfecta. It has been studied in the treatment of complex regional pain syndrome.
Common side effects include bone pain, low calcium levels, nausea, and dizziness. Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including pamidronate.
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