From WikiProjectMed
Jump to navigation Jump to search
Fibrous papule of the nose (DermNet NZ lesions-fibrous-papule2).jpg
Angiofibroma of the nose
TypesPearly penile papules, fibrous papules of the face, adenoma sebaceum, acral fibrokeratoma,[1]
CausesLocal overgrowth of fibroblasts, collagen and blood vessels[2]

Angiofibroma is a small bump in the skin classified by where in the body it appears or by its association with a genetic condition.[2] Acquired types include pearly penile papules, fibrous papules of the face and acral fibrokeratoma,[1] which includes angiofibromas under the nail and those at the fingertip.[3] Angiofibroma may be associated with tuberous sclerosis, Birt-Hogg-Dubé syndrome and multiple endocrine neoplasia type 1.[1]

Angiofibromas are caused by a local overgrowth of blood vessels, collagen and fibroblasts.[2] The angiofibromas in tuberous sclerosis, also called adenoma sebaceum, usually appear in childhood, are small, yellow-brown or flesh-colored, smooth, shiny, 0.1 to 0.3 cm bumps present over the sides of the nose and the cheeks, in a butterfly distribution.[3][2] Later, oral fibroma or a periungal angiofibroma may appear.[2] A solitary fibrous papule typically occurring on the nose in an adult, and pearly penile papules are acquired angiofibromas.[2] Angiofibromas may be itchy, bleed and cause disfigurement.[2]

Diagnosis is by visualisation and biopsy.[2] Facial angiofibromas may appear similar to acne, basal cell carcinoma or intradermal nevus.[2] Viral warts and subungal exostosis can appear like angiofibromas in the nail.[2] Pearly penile papules can mimic molluscum contagiosum and genital warts.[2] Treatment is not always necessary.[2] Some options include excision, dermabrasion, lasers, electrical and radiofrequency procedures, cryotherapy, topical podophyllotoxin, topical rapamycin, or topical beta-blocker.[2]


See also


  1. 1.0 1.1 1.2 Johnstone, Ronald B. (2017). "38. Vascular tumors". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 709. ISBN 978-0-7020-6830-0. Archived from the original on 2021-05-25. Retrieved 2021-09-24.
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 "Angiofibroma". Archived from the original on 13 August 2021. Retrieved 24 September 2021.
  3. 3.0 3.1 Johnstone, Ronald B. (2017). "34. Fibrous tumors and tumor-like proliferations". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. pp. 613–616. ISBN 978-0-7020-6830-0. Archived from the original on 2021-05-25. Retrieved 2021-09-24.

External links