Angiofibroma
| Angiofibroma | |
|---|---|
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| Angiofibroma of the nose | |
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| Specialty | Dermatology |
| Types | Pearly penile papules, fibrous papules of the face, adenoma sebaceum, acral fibrokeratoma,[1] |
| Causes | Local overgrowth of fibroblasts, collagen and blood vessels[2] |
Angiofibroma is a small bump in the skin classified by where in the body it appears or by its association with a genetic condition.[2] Acquired types include pearly penile papules, fibrous papules of the face and acral fibrokeratoma,[1] which includes angiofibromas under the nail and those at the fingertip.[3] Angiofibroma may be associated with tuberous sclerosis, Birt-Hogg-Dubé syndrome and multiple endocrine neoplasia type 1.[1]
Angiofibromas are caused by a local overgrowth of blood vessels, collagen and fibroblasts.[2] The angiofibromas in tuberous sclerosis, also called adenoma sebaceum, usually appear in childhood, are small, yellow-brown or flesh-colored, smooth, shiny, 0.1 to 0.3 cm bumps present over the sides of the nose and the cheeks, in a butterfly distribution.[3][2] Later, oral fibroma or a periungal angiofibroma may appear.[2] A solitary fibrous papule typically occurring on the nose in an adult, and pearly penile papules are acquired angiofibromas.[2] Angiofibromas may be itchy, bleed and cause disfigurement.[2]
Diagnosis is by visualisation and biopsy.[2] Facial angiofibromas may appear similar to acne, basal cell carcinoma or intradermal nevus.[2] Viral warts and subungal exostosis can appear like angiofibromas in the nail.[2] Pearly penile papules can mimic molluscum contagiosum and genital warts.[2] Treatment is not always necessary.[2] Some options include excision, dermabrasion, lasers, electrical and radiofrequency procedures, cryotherapy, topical podophyllotoxin, topical rapamycin, or topical beta-blocker.[2]
Images
Angiofibromas face (butterfly distribution)
Angiofibromas in tuberous sclerosis
Angiofibromas in tuberous sclerosis
Fibrous papule of the nose
Fibrous papule of the nose
Angiofibroma in mouth
Angiofibroma inside cheek
Angiofibroma at fingertip (acquired fibrokeratoma)
Angiofibroma under nail
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See also
References
- ↑ 1.0 1.1 1.2 Johnstone, Ronald B. (2017). "38. Vascular tumors". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 709. ISBN 978-0-7020-6830-0. Archived from the original on 2021-05-25. Retrieved 2021-09-24.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 "Angiofibroma". dermnetnz.org. Archived from the original on 13 August 2021. Retrieved 24 September 2021.
- ↑ 3.0 3.1 Johnstone, Ronald B. (2017). "34. Fibrous tumors and tumor-like proliferations". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. pp. 613–616. ISBN 978-0-7020-6830-0. Archived from the original on 2021-05-25. Retrieved 2021-09-24.
External links
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