Wernicke encephalopathy

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Wernicke encephalopathy
Other names: Cerebral beriberi,[1] Wernicke's disease, Wernicke's encephalopathy[2]
SymptomsAbnormal movement of the eyes, poor coordination, confusion[3]
ComplicationsKorsakoff syndrome[3]
Usual onsetSudden[3]
CausesThiamine deficiency[3]
Risk factorsAlcohol use disorder, malnutrition[4]
Diagnostic methodBased on symptoms[3]
Differential diagnosisAlcohol withdrawal, electrolyte disorders, infection, drugs of abuse, head trauma[4]
TreatmentThiamine supplements[3]
Deaths15% without treatment[3]

Wernicke encephalopathy (WE) is a brain disorder that classically results in – abnormal movement of the eyes, poor coordination, and confusion.[3] Around 10% of people exhibit all three features, with confusion being the most common.[4][6] It is generally of sudden onset.[3] When people walk they usually have their feet apart and take small steps.[3]

It occurs due to thiamine deficiency.[3] Risk factors include alcohol use disorder and malnutrition, though genetics may also play a role.[3] Causes of malnutrition may include nausea and vomiting of pregnancy, eating disorders, or cancer.[4] Diagnosis is generally based on symptoms; though may be supported by measuring blood thiamine levels.[3][4] Without treatment about 80% of cases are complicated by Korsakoff syndrome, with its associated memory problems.[4] The combination is known as Wernicke–Korsakoff syndrome.[3]

Treatment is with thiamine supplementation, which can lead to improvement within days to weeks, though some are left with permanent problems.[4] Often a thiamine dose of 100 to 200 mg, one to three times per day, injected into a vein, for 3 to 5 days is used.[4] Low magnesium should be treated if present.[3] Without treatment about 15% of people die.[3]

Wernicke's occurs in around 2% of people; though up to 12.5% of people with alcohol use disorder and 10% of people with AIDS are affected.[5] The condition is believed to be underdiagnosed.[4] It was initially described in 1881 by Carl Wernicke.[4]

Signs and symptoms

The classic triad of symptoms found in Wernicke encephalopathy is:[7]

However, in actuality, only a small percentage of patients experience all three symptoms,[8] and the full triad occurs more frequently among those who have overused alcohol.

Also a much more diverse range of symptoms has been found in patients with this condition, including:

Although hypothermia is usually diagnosed with a body temperature of 35 °C / 95° Fahrenheit, or less, incipient cooling caused by deregulation in the central nervous system (CNS) needs to be monitored because it can promote the development of an infection.[14] The patient may report feeling cold, followed by mild chills, cold skin, moderate pallor, tachycardia, hypertension, tremor or piloerection. External warming techniques are advised to prevent hypothermia.[citation needed]

Among the frequently altered functions are the cardio circulatory. There may be tachycardia, dyspnea, chest pain, orthostatic hypotension, changes in heart rate and blood pressure.[25] The lack of thiamine sometimes affects other major energy consumers, the myocardium, and also patients may have developed cardiomegaly.[26] Heart failure with lactic acidosis syndrome has been observed.[27] Cardiac abnormalities are an aspect of the WE, which was not included in the traditional approach,[28][29] and are not classified as a separate disease. Infections have been pointed out as one of the most frequent triggers of death in WE.[29][30] Furthermore, infections are usually present in pediatric cases.[31][32]

In the last stage other symptoms may occur: hyperthermia, increased muscle tone, spastic paralysis, choreic dyskinesias and coma.[citation needed]

Because of the frequent involvement of heart, eyes and peripheral nervous system, several authors prefer to call it Wernicke disease rather than simply encephalopathy.[28][33]

Early symptoms are nonspecific,[34][35] and it has been stated that WE may present nonspecific findings.[36] In Wernicke Korsakoff's syndrome some single symptoms are present in about one-third.[37]

Korsakoff syndrome

Korsakoff syndrome, characterised by memory impairment, confabulation, confusion and personality changes, has a strong and recognised link with WE.[38][39] A very high percentage of patients with Wernicke–Korsakoff syndrome also have peripheral neuropathy, and many people who consume excess alcohol have this neuropathy without other neurologic signs or symptoms.[40] Korsakoff's occurs much more frequently in WE due to chronic alcoholism.[39] It is uncommon among those who do not consume excessive amounts of alcohol. Up to 80% of WE patients who misuse alcohol develop Korsakoff's syndrome.[36] In Korsakoff's, is usually observed atrophy of the thalamus and the mammillary bodies, and frontal lobe involvement.[36] In a study, half of Wernicke-Korsakoff cases had good recovery from the amnesic state, which may take from 2 months to 10 years.[citation needed]

Risk factors

Wernicke encephalopathy has classically been thought of as a disease solely of people who drink excessive amounts of alcohol, but it is also found in the chronically undernourished, and in recent years had been discovered post bariatric surgery.[7][36] Without being exhaustive, the documented causes of Wernicke encephalopathy have included:


Thiamine deficiency and errors of thiamine metabolism are believed to be the primary cause of Wernicke encephalopathy. Thiamine, also called B1, helps to break down glucose. Specifically, it acts as an essential coenzyme to the TCA cycle and the pentose phosphate shunt. Thiamine is first metabolised to its more active form, thiamine diphosphate (TDP), before it is used. The body only has 2–3 weeks of thiamine reserves, which are readily exhausted without intake, or if depletion occurs rapidly, such as in chronic inflammatory states or in diabetes.[7][36] Thiamine is involved in:[36][45]

  1. Metabolism of carbohydrates, releasing energy.
  2. Production of neurotransmitters including glutamic acid and GABA.
  3. Lipid metabolism, necessary for myelin production.
  4. Amino acid modification. Probably linked to the production of taurine, of great cardiac importance.[46][47]


The primary neurological-related injury caused by thiamine deficiency in WE is three-fold: oxidative damage, mitochondrial injury leading to apoptosis, and directly stimulating a pro-apoptotic pathway.[48] Thiamine deficiency affects both neurons and astrocytes, glial cells of the brain. Thiamine deficiency alters the glutamate uptake of astrocytes, through changes in the expression of astrocytic glutamate transporters EAAT1 and EAAT2, leading to excitotoxicity. Other changes include those to the GABA transporter subtype GAT-3, GFAP, glutamine synthetase, and the Aquaporin 4 channel.[49] Focal lactic acidosis also causes secondary oedema, oxidative stress, inflammation and white matter damage.[50]

Depending on the location of the brain lesion different symptoms are more frequent:[citation needed]

  • Brainstem tegmentum. - Ocular: pupillary changes. Extraocular muscle palsy; gaze palsy: nystagmus.
  • Hypothalamus. Medulla: dorsal nuc. of vagus. - Autonomic dysfunction: temperature; cardiocirculatory; respiratory.
  • Medulla: vestibular region. Cerebellum. - Ataxia.
  • Dorsomedial nuc. of thalamus. Mammillary bodies. - Amnestic syndrome for recent memory.

Mamillary lesion are characteristic-small petechial hemorrhages are found.

  • Diffuse cerebral dysfunction.- Altered cognition: global confusional state.
  • Brainstem: periaqueductal gray.- Reduction of consciousness[51]
  • Hypothalamic lesions may also affect the immune system, which is known in people who consume excessive amounts of alcohol, causing dysplasias and infections.

Pathological anatomy


Despite its name, WE is not related to Wernicke's area, a region of the brain associated with speech and language interpretation.[citation needed]

In most, early lesions completely reversed with immediate and adequate supplementation.[citation needed]

Lesions are usually symmetrical in the periventricular region, diencephalon, the midbrain, hypothalamus, and cerebellar vermis. Brainstem lesions may include cranial nerve III, IV, VI and VIII nuclei, the medial thalamic nuclei, and the dorsal nucleus of the vagus nerve. Oedema may be found in the regions surrounding the third ventricle, and fourth ventricle, also appearing petechiae and small hemorrhages.[52] Chronic cases can present the atrophy of the mammillary bodies.[53]

Endothelial proliferation, hyperplasia of capillaries, demyelination and neuronal loss can also occur.[citation needed]

An altered blood–brain barrier may cause a perturbed response to certain drugs and foods.[54]


Magnetic resonance imaging shows characteristic Wernicke's encephalopathy with T2 signal hyper-intensity in the periaqueductal area (arrow).

Diagnosis of Wernicke encephalopathy or disease is made clinically.[42][55] Caine et al. in 1997 established criteria that Wernicke encephalopathy can be diagnosed in any patient with just two or more of the main symptoms noted above.[56] The sensitivity of the diagnosis by the classic triad was 23% but increased to 85% taking two or more of the four classic features. This criteria is challenged because all the cases he studied were people who drank excessive amounts of alcohol. Some consider it sufficient to suspect the presence of the disease with only one of the principal symptoms.[57] Some British hospital protocols suspect WE with any one of these symptoms: confusion, decreased consciousness level (or unconsciousness, stupor or coma), memory loss, ataxia or unsteadiness, ophthalmoplegia or nystagmus, and unexplained hypotension with hypothermia. The presence of only one sign should be sufficient for treatment.[58]

As a much more diverse range of symptoms has been found frequently in patients it is necessary to search for new diagnostic criteria, however Wernicke encephalopathy remains a clinically-diagnosed condition. Neither the MR, nor serum measurements related to thiamine are sufficient diagnostic markers in all cases. However, as described by Zuccoli et al. in several papers the involvement of the cranial nerve nuclei and central gray matter on MRI, is very specific to WE in the appropriate clinical setting.[53] Non-recovery upon supplementation with thiamine is inconclusive.[citation needed]

The sensitivity of MR was 53% and the specificity was 93%. The reversible cytotoxic edema was considered the most characteristic lesion of WE. The location of the lesions were more frequently atypical among people who drank appropriate amounts of alcohol, while typical contrast enhancement in the thalamus and the mammillary bodies was observed frequently associated with alcohol misuse.[53] These abnormalities may include:[7]

There appears to be very little value for CT scans.[42]

Thiamine can be measured using an erythrocyte transketolase activity assay,[42] or by activation by measurement of in vitro thiamine diphosphate levels.[42] Normal thiamine levels do not necessarily rule out the presence of WE,[42] as this may be a patient with difficulties in intracellular transport.


There are hospital protocols for prevention, supplementing with thiamine in the presence of: history of alcohol misuse or related seizures, requirement for IV glucose, signs of malnutrition, poor diet, recent diarrhea or vomiting, peripheral neuropathy, intercurrent illness, delirium tremens or treatment for DTs, and others.[58][60] Some experts advise parenteral thiamine should be given to all at-risk patients in the Emergency Department.[42]

In the clinical diagnosis should be remembered that early symptoms are nonspecific,[34][35] and it has been stated that WE may present nonspecific findings.[36] There is consensus to provide water-soluble vitamins and minerals after gastric operations.[citation needed]

In some countries certain foods have been supplemented with thiamine, and have reduced WE cases. Improvement is difficult to quantify because they applied several different actions. Avoiding or moderating alcohol consumption and having adequate nutrition reduces one of the main risk factors in developing Wernicke-Korsakoff syndrome.[citation needed]


Most symptoms will improve quickly if deficiencies are treated early. Memory disorder may be permanent.[61]

In patients suspected of WE, thiamine treatment should be started immediately.[36] Blood should be immediately taken to test for thiamine, other vitamins and minerals levels. Following this an immediate intravenous or intramuscular dose of thiamine should be administered[33] two or three times daily. Thiamine administration is usually continued until clinical improvement ceases.[citation needed]

Considering the diversity of possible causes and several surprising symptomatologic presentations, and because there is low assumed risk of toxicity of thiamine, because the therapeutic response is often dramatic from the first day, some qualified authors indicate parenteral thiamine if WE is suspected, both as a resource for diagnosis and treatment.[42] The diagnosis is highly supported by the response to parenteral thiamine, but is not sufficient to be excluded by the lack of it.[62] Parenteral thiamine administration is associated with a very small risk of anaphylaxis.[citation needed]

People who consume excessive amounts of alcohol may have poor dietary intakes of several vitamins, and impaired thiamine absorption, metabolism, and storage; they may thus require higher doses.[34]

If glucose is given, such as in people with an alcohol use disorder who are also hypoglycaemic, thiamine must be given concurrently. If this is not done, the glucose will rapidly consume the remaining thiamine reserves, exacerbating this condition.[36]

The observation of edema in MR, and also the finding of inflation and macrophages in necropsied tissues,[52] has led to successful administration of antiinflammatories.[63][64]

Other nutritional abnormalities should also be looked for, as they may be exacerbating the disease.[30][65] In particular, magnesium, a cofactor of transketolase which may induce or aggravate the disease.[36]

Other supplements may also be needed, including: cobalamin, ascorbic acid, folic acid, nicotinamide, zinc,[66][67] phosphorus (dicalcium phosphate)[68] and in some cases taurine, especially suitable when there cardiocirculatory impairment.[69][70] Patient-guided nutrition is suggested. In patients with Wernicke-Korsakoff syndrome, even higher doses of parenteral thiamine are recommended. Concurrent toxic effects of alcohol should also be considered.[39][68]


Epidemiology of WE[71]

There are no conclusive statistical studies, all figures are based on partial studies.

Wernicke's lesions were observed in 0.8 to 2.8% of the general population autopsies, and 12.5% of people with an alcohol use disorder. This figure increases to 35% of such individuals if including cerebellar damage due to lack of thiamine.[72]

Most autopsy cases were from people with an alcohol use disorder. Autopsy series were performed in hospitals on the material available which is unlikely to be representative of the entire population. Considering the slight affectations, previous to the generation of observable lesions at necropsy, the percentage should be higher. There is evidence to indicate that Wernicke encephalopathy is underdiagnosed.[8][73] For example, in one 1986 study, 80% of cases were diagnosed postmortem.[8] Is estimated that only 5–14% of patients with WE are diagnosed in life.[74]

In a series of autopsy studies held in Recife, Brazil, it was found that only 7 out of 36 had consumed excessive amounts of alcohol, and only a small minority had malnutrition.[75] In a reviewed of 53 published case reports from 2001 to 2011, the relationship with alcohol was also about 20% (10 out of 53 cases).[7]

WE is more likely to occur in males than females.[36] Among the minority who are diagnosed, mortality can reach 17%.[28] The main factors triggering death are thought to be infections and liver dysfunctions.[28]


WE was first identified in 1881 by the German neurologist Carl Wernicke, although the link with thiamine was not identified until the 1930s. A similar presentation of this disease was described by the Russian psychiatrist Sergei Korsakoff in a series of articles published 1887–1891.[7]


  • Infants and children. No one present clinical triad : infections, heart diseases, etc.[31]
  • In children. infection on 22/36 cases, etc.[76]
  • Difficulties in diagnosing, pediatric statistics.[76]
  • Secondary microcephaly: poor transport of thiamine pyrophosphate.[77]


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