Muzolimine
Jump to navigation
Jump to search
Clinical data | |
---|---|
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.054.139 |
Chemical and physical data | |
Formula | C11H11Cl2N3O |
Molar mass | 272.13 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
Muzolimine is a high-ceiling loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]
Synthesis
Rxn of (1-(3,4-dichlorophenyl)ethyl)hydrazine (1) with ethyl 3-amino-3-ethoxyacrylate (2) leads to a ring-forming two-site reaction and formation of the pyrazoline diuretic agent, muzolimine (3).
References
- ^ Wangemann P, Braitsch R, Greger R (December 1987). "The diuretic effect of muzolimine". Pflügers Archiv. 410 (6): 674–6. doi:10.1007/BF00581331. PMID 3449804. S2CID 19367481.
- ^ Reyes AJ, Leary WP (January 1993). "Clinicopharmacological reappraisal of the potency of diuretics". Cardiovascular Drugs and Therapy. 7 Suppl 1: 23–8. doi:10.1007/BF00877955. PMID 8435374. S2CID 29589710.
- ^ DE 2319278, Möller, Eike; Meng, Karl & Wehinger, Egbert et al., "Diuretisches und antihypertensives Mitel [Diuretic and antihypertensive agent]", published 1974-11-07, assigned to Bayer AG
- ^ E. Möller et al., U.S. patent 3,957,814 (1976 to Bayer); eidem, Experientia 33, 382 (1977).
Categories:
- CS1: long volume value
- Articles with short description
- Short description matches Wikidata
- Drugs with non-standard legal status
- Articles with changed CASNo identifier
- Articles with changed ChemSpider identifier
- ECHA InfoCard ID from Wikidata
- Articles with changed InChI identifier
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- Diuretics
- Chloroarenes
- Pyrazolones
- All stub articles
- Cardiovascular system drug stubs