|Drug class||Thiazide-like diuretic|
|Main uses||High blood pressure, swelling|
|Side effects||Low potassium, headache, dizziness, tiredness, numbness, anxiety|
|Typical dose||1.25 to 2.5 mg OD|
|Elimination half-life||14–18 hours|
|Chemical and physical data|
|Molar mass||365.83 g·mol−1|
|3D model (JSmol)|
Indapamide is a medication used to treat high blood pressure and swelling due to heart failure or other causes. It is a second line treatment for high blood pressure in pregnancy. It is taken by mouth. It may be used with other blood pressure medications.
Common side effects include low potassium, headache, dizziness, tiredness, numbness, and anxiety. Other side effects may include low sodium, rash, gout, and high blood sugar. It is a thiazide-like diuretic.
Indapamide was patented in 1968 and approved for medical use in 1977. It is available as a generic medication. In the United Kingdom it costs the NHS about £3.40 a month as of 2021. In the United States this amount costs about 4 USD per month. A combination medication with perindopril is also available.
Its indications include hypertension and edema due to congestive heart failure. Indapamide has been shown to reduce stroke rates in people over the age of 52. When used in combination with perindopril, evidence from multiple studies show a greater reduction in stroke occurrence. In the HYVET study, indapamide has been demonstrated to reduce all-cause mortality in octogenarians regardless of the addition of perindopril.[non-primary source needed]
Thiazide-like diuretics (indapamide and chlorthalidone) appear to be more effective than the thiazide-type diuretics (hydrochlorothiazide) in reducing risks of major cardiovascular events and heart failure in persons with high blood pressure. In terms of stroke risk, both thiazide-type and thiazide-like diuretics are effective in reducing it.
The adult dosage is 1.25 to 2.5 mg, orally and once daily, usually in the morning.
Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets. It is also available in SR (sustained release) form.
Commonly reported side effects are low potassium levels, fatigue, orthostatic hypotension (an exaggerated decrease in blood pressure upon standing, often associated with syncope), and allergic manifestations.
Caution is advised in the combination of indapamide with lithium and drugs causing prolonged QT interval (on EKG) or wave-burst arrhythmia (ie: astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, and vincamine).
Symptoms of over dosage would be those associated with a diuretic effect (ie electrolyte disturbances), low blood pressure, and muscular weakness. Treatment should be symptomatic, directed at correcting electrolyte abnormalities.
Society and culture
The cost in the U.S. of this medication is $41 (USD) for 100 tablets ( 2.5 mg)
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